ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2017
The long reach of early adversity: Parenting, stress, and neural pathways to antisocial behavior in adulthood.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 66 citations in OpenAlex.
- Early life adversity shapes neural and behavioural responses to oxytocin during altruistic decision-making.Translational psychiatry · 2026Article
- Early Relational Health and its Impact on the Developing Brain: A Scoping Review.Clinical child and family psychology review · 2026Article
- Gene-Environment Interplay Beyond Interactions: Psychosocial Environments Mediate Genetic Effects Underlying Externalizing-Behavior Trajectories.Clinical psychological science : a journal of the Association for Psychological Science · 2026Article
- Longitudinal dynamics of harsh parenting and non-suicidal self-injury in Chinese adolescents: a three-wave RI-CLPM with basic psychological needs frustration as a mediator.BMC psychology · 2026Article
- Annual Research Review: Early conduct problems - precursors, outcomes, and etiology.Journal of child psychology and psychiatry, and allied disciplines · 2026Review
- Parental Warmth and Emotion Reactivity in the Brain: Differences by Assigned Sex.Social development (Oxford, England) · 2025Article
- The Big Minority View: Do Prescientific Beliefs Underpin Criminal Justice Cruelty, and Is the Public Health Quarantine Model a Remedy?International journal of environmental research and public health · 2025Article
- Self-Efficacy and Psychological Well-Being in Adolescents: Evaluating the Moderating Role of Socioeconomic Status and Cultural Factors.Pediatric reports · 2025Article
- Exploring the Role of Empathy in the Association Between Early Life Adversity and Antisocial Behavior.Affective science · 2025Article
- Exposure to community violence as a mechanism linking neighborhood disadvantage to amygdala reactivity and the protective role of parental nurturance.Developmental psychology · 2024Article
- Disgust sensitivity and psychopathic behavior: A narrative review.Translational neuroscience · 2024Review
- Individual and Combined Effect ofBehavioral sciences (Basel, Switzerland) · 2023Article
- Neighborhood disadvantage, race/ethnicity and neural sensitivity to social threat and reward among adolescents.Social cognitive and affective neuroscience · 2023Article
- Amygdala reactivity during socioemotional processing and cortisol reactivity to a psychosocial stressor.Psychoneuroendocrinology · 2022Article
- Prospective longitudinal associations between harsh parenting and corticolimbic function during adolescence.Development and psychopathology · 2022Article
- Deadly gun violence, neighborhood collective efficacy, and adolescent neurobehavioral outcomes.PNAS nexus · 2022Article
- The impact of neighborhood disadvantage on amygdala reactivity: Pathways through neighborhood social processes.Developmental cognitive neuroscience · 2022Article
- Effects of Parenting Environment on Child and Adolescent Social-Emotional Brain Function.Current topics in behavioral neurosciences · 2022Review
- The Impact of the COVID-19 Pandemic on Children's Conduct Problems and Callous-Unemotional Traits.Child psychiatry and human development · 2021Article
- Early Impacts of Room to Grow: A Multifaceted Intervention Supporting Parents and Children Age Zero to Three.Children and youth services review · 2021Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundEarly life adversities including harsh parenting, maternal depression, neighborhood deprivation, and low family economic resources are more prevalent in low-income urban environments and are potent predictors of psychopathology, including, for boys, antisocial behavior (AB). However, little research has examined how these stressful experiences alter later neural function. Moreover, identifying genetic markers of greater susceptibility to adversity is critical to understanding biopsychosocial pathways from early adversity to later psychopathology.
methodsWithin a sample of 310 low-income boys followed from age 1.5 to 20, multimethod assessments of adversities were examined at age 2 and age 12. At age 20, amygdala reactivity to emotional facial expressions was assessed using fMRI, and symptoms of Antisocial Personality Disorder were assessed via structured clinical interview. Genetic variability in cortisol signaling (
resultsObserved parenting and neighborhood deprivation at age 2 each uniquely predicted amygdala reactivity to emotional faces at age 20 over and above other adversities measured at multiple developmental periods. Harsher parenting and greater neighborhood deprivation in toddlerhood predicted clinically-significant symptoms of AB via less amygdala reactivity to fearful facial expressions and this pathway was moderated by genetic variation in
conclusionsThese results elucidate a pathway linking early adversity to less amygdala reactivity to social signals of interpersonal distress 18 years later, which in turn increased risk for serious AB. Moreover, these findings suggest a genetic marker of youth more susceptible to adversity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.