Evidence map›Paper›PMID 29170720›Full record

ArticleLiver research (Beijing, China)2017

Methionine adenosyltransferases in liver health and diseases.

Komal Ramani, Shelly C Lu

Open access · goldAbstract read
In one paragraph

Article in Liver research (Beijing, China), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 54 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. A novel role of secreted methionine adenosyltransferase α2 in colorectal liver metastases.Journal of experimental & clinical cancer research : CR · 2025
    Article
  8. Article
  9. Mechanisms and rationales of SAM homeostasis.Trends in biochemical sciences · 2025
    Review
  10. Article
  11. Article
  12. Article
  13. Deciphering the Role of Oroxylin A in Liver Fibrosis.Drug design, development and therapy · 2025
    Review
  14. Article
  15. Subcellular one carbon metabolism in cancer, aging and epigenetics.Frontiers in epigenetics and epigenomics · 2024
    Article
  16. Article
  17. Review
  18. Dysregulated DNA methylation in the pathogenesis of Fabry disease.Molecular genetics and metabolism reports · 2022
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Komal RamaniDivision of Digestive and Liver Diseases, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Shelly C LuDivision of Digestive and Liver Diseases, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Cedars-Sinai Medical Center · US

Funding

USC RESEARCH CENTER FOR LIVER DISEASES: PILOT PROGRAMSP30DK048522 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KAPLOWITZ, NEIL · 1995 to 2020
$21.8M
REGULATION OF S-ADENOSYLMETHIONINE SYNTHETASE IN LIVERR01DK051719 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LU, SHELLY CHI-LOO · 1997 to 2014
$4.5M
S-Adenosylmethionine in Protein Posttranslational Modifications and HCC TreatmentR01DK107288 · NIDDK · CEDARS-SINAI MEDICAL CENTER · PI LU, SHELLY CHI-LOO · 2015 to 2018
$1.6M
NIDDK NIH HHS P30 DK048522NIDDK NIH HHS R01 DK051719NIDDK NIH HHS R01 DK107288
6 · The paper itself

Abstract

Methionine adenosyltransferases (MATs) are essential for cell survival because they catalyze the biosynthesis of the biological methyl donor S-adenosylmethionine (SAMe) from methionine and adenosine triphosphate (ATP). Mammalian cells express two genes,

Indexed as

Hepatocellular carcinomaLiver injuryMethionine adenosyltransferasesS-adenosylmethionine

Identifiers

PMID29170720
PMCPMC5695885
OpenAlexW2740000888

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.