Evidence map›Paper›PMID 29170670›Full record

ArticleFrontiers in immunology2017

Metabolic Adaptation of Human CD4

Nicholas Jones, James G Cronin, Garry Dolton, Silvia Panetti, Andrea J Schauenburg, Sarah A E Galloway, Andrew K Sewell, David K Cole, Catherine A Thornton, Nigel J Francis

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 86 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Nanomaterials Trigger Functional Anti-Tumoral Responses in Primary Human Immune Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  5. Cell type-specific purifying selection of synonymous mitochondrial DNA variation.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Glycolysis: An early marker for vancomycin-specific T-cell activation.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2024
    Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. PFKP: More than phosphofructokinase.Advances in cancer research · 2023
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Nicholas JonesInstitute of Life Science, Medical School, Swansea University, Swansea, United Kingdom.
James G CroninInstitute of Life Science, Medical School, Swansea University, Swansea, United Kingdom.
Garry DoltonCardiff University School of Medicine, Cardiff, United Kingdom.
Silvia PanettiInstitute of Life Science, Medical School, Swansea University, Swansea, United Kingdom.
Andrea J SchauenburgCardiff University School of Medicine, Cardiff, United Kingdom.
Sarah A E GallowayCardiff University School of Medicine, Cardiff, United Kingdom.
Andrew K SewellCardiff University School of Medicine, Cardiff, United Kingdom.
David K ColeCardiff University School of Medicine, Cardiff, United Kingdom.
Catherine A ThorntonInstitute of Life Science, Medical School, Swansea University, Swansea, United Kingdom.
Nigel J FrancisInstitute of Life Science, Medical School, Swansea University, Swansea, United Kingdom.
Cardiff University · GBSwansea University · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

Linking immunometabolic adaptation to T-cell function provides insight for the development of new therapeutic approaches in multiple disease settings. T-cell activation and downstream effector functions of CD4

Indexed as

GLUT1glycolysisimmunometabolismmetabolismT-cellT-cell receptor

Identifiers

PMID29170670
PMCPMC5684100
OpenAlexW2767589352

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.