Evidence map›Paper›PMID 29170665›Full record

ArticleFrontiers in immunology2017

Canonical Stimulation of the NLRP3 Inflammasome by Fungal Antigens Links Innate and Adaptive B-Lymphocyte Responses by Modulating IL-1β and IgM Production.

Mohamed F Ali, Harika Dasari, Virginia P Van Keulen, Eva M Carmona

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 63 citations in OpenAlex.

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  9. Role of inflammasomes in cancer immunity: mechanisms and therapeutic potential.Journal of experimental & clinical cancer research : CR · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Mohamed F AliThe Thoracic Diseases Research Unit and the Division of Pulmonary and Critical Care, Department of Medicine Mayo Clinic and Foundation, Rochester, MN, United States.
Harika DasariThe Thoracic Diseases Research Unit and the Division of Pulmonary and Critical Care, Department of Medicine Mayo Clinic and Foundation, Rochester, MN, United States.
Virginia P Van KeulenThe Thoracic Diseases Research Unit and the Division of Pulmonary and Critical Care, Department of Medicine Mayo Clinic and Foundation, Rochester, MN, United States.
Eva M CarmonaThe Thoracic Diseases Research Unit and the Division of Pulmonary and Critical Care, Department of Medicine Mayo Clinic and Foundation, Rochester, MN, United States.
Mayo Clinic · US

Funding

Modulation of host immune defense by Pneumocystis beta-glucansK08HL112849 · NHLBI · MAYO CLINIC ROCHESTER · PI CARMONA PORQUERA, EVA MARIA · 2013 to 2017
$712k
NHLBI NIH HHS K08 HL112849
6 · The paper itself

Abstract

The NLRP3 inflammasome is activated in response to different bacterial, viral, and fungal pathogens and serves as modulator of different pattern recognition receptors signaling pathways. One of the main functions of NLRP3 is to participate in IL-1β maturation which is important in the host defense against

Indexed as

B-lymphocytesCpGfungiIgMIL-1βinflammasomeNLRP3β-glucan

Identifiers

PMID29170665
PMCPMC5684107
OpenAlexW2767956934

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.