ArticleScientific reports2017
Increased light penetration due to ultrasound-induced air bubbles in optical scattering media.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed.
- Combined Effects of Focused Ultrasound and Photodynamic Treatment for Malignant Brain Tumors Using C6 Glioma Rat Model.Yonsei medical journal · 2023Article
- Transrectal Ultrasound and Photoacoustic Imaging Probe for Diagnosis of Prostate Cancer.Sensors (Basel, Switzerland) · 2021Article
- Anisotropic scattering characteristics of nanoparticles in different morphologies: improving the temperature uniformity of tumors during thermal therapy using forward scattering.Biomedical optics express · 2021Article
- Improvement of light penetration in biological tissue using an ultrasound-induced heating tunnel.Scientific reports · 2020Article
- Ultrasound-assisted photothermal therapy and real-time treatment monitoring.Biomedical optics express · 2018Article
- Multimodal photoacoustic imaging as a tool for sentinel lymph node identification and biopsy guidance.Biomedical engineering letters · 2018Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Light is an attractive tool for high spatial- and contrast-resolution imaging, highly sensitive molecular imaging, and target-selective therapy, and it does not exhibit the risks associated with ionizing radiation. The main limitation of using light in clinical applications is its superficial imaging and therapeutic depth caused by high optical scattering in biological media. Here, we demonstrate that the scattering and thus defocusing of the incident light can be alleviated when simultaneously delivered ultrasound generates air bubbles in the pathway of the incident light, thus increasing the light penetration. The bubbles are temporally induced by ultrasound with an intensity that is sufficiently low to avoid tissue damage and act as a Mie scattering medium in which light is scattered predominantly in the forward direction. The change in the optical scattering property caused by the ultrasound is undone after cessation of the insonification. From the results, it is expected that this proposed method will open a new route for overcoming the limitations of current optical imaging and therapeutic techniques.
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Registered trials
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