ArticleScientific reports2017
Identification and analysis of seven effector protein families with different adaptive and evolutionary histories in plant-associated members of the Xanthomonadaceae.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 49 citations in OpenAlex.
- Unlocking the genetic arsenal of Xanthomonas arboricola: new insights into taxonomic classification, pathogenicity and adaptation beyond the effectorome.BMC genomics · 2026Article
- Functional Cargo in Membrane Vesicles From a Citrus Pathogen.Environmental microbiology reports · 2025Article
- From cactus to crop: genomic insights of a beneficial and non-pathogenic Curtobacterium flaccumfaciens strain and the evolution of its pathosystem.Molecular genetics and genomics : MGG · 2024Article
- Comparative transcriptomics reveals a highly polymorphic Xanthomonas HrpG virulence regulon.BMC genomics · 2024Article
- Genome Organization of Four Brazilian Xanthomonas albilineans Strains Does Not Correlate with Aggressiveness.Microbiology spectrum · 2023Article
- Comparative Genomics ofMicroorganisms · 2022Article
- Gut microbiota is involved in the antidepressant effects of adipose-derived mesenchymal stem cells in chronic social defeat stress mouse model.Psychopharmacology · 2022Article
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- Comparison and interpretation of characteristics of Rhizosphere microbiomes of three blueberry varieties.BMC microbiology · 2021Article
- Intestinal inflammation alters mucosal carbohydrate foraging and monosaccharide incorporation into microbial glycans.Cellular microbiology · 2021Article
- Proteome Analysis of Walnut Bacterial Blight Disease.International journal of molecular sciences · 2020Article
- Whole genome sequencing and identification of host-interactive genes in the rice endophytic Leifsonia sp. ku-ls.Functional & integrative genomics · 2020Article
- Genome-Wide Profiling and Phylogenetic Analysis of theInternational journal of molecular sciences · 2020Article
- Composition, Predicted Functions and Co-occurrence Networks of Rhizobacterial Communities Impacting Flowering Desert Events in the Atacama Desert, Chile.Frontiers in microbiology · 2020Article
- Trans-Graft Protection Against Pierce's Disease Mediated by Transgenic Grapevine Rootstocks.Frontiers in plant science · 2019Article
- Gene Tags Assessment by Comparative Genomics (GTACG): A User-Friendly Framework for Bacterial Comparative Genomics.Frontiers in genetics · 2019Article
- Arabidopsis thaliana responds to colonisation of Piriformospora indica by secretion of symbiosis-specific proteins.PloS one · 2018Article
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Authors and funding
15 authors at 6 institutions in 3 countries.
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No grant is acknowledged in the PubMed record.
Abstract
The Xanthomonadaceae family consists of species of non-pathogenic and pathogenic γ-proteobacteria that infect different hosts, including humans and plants. In this study, we performed a comparative analysis using 69 fully sequenced genomes belonging to this family, with a focus on identifying proteins enriched in phytopathogens that could explain the lifestyle and the ability to infect plants. Using a computational approach, we identified seven phytopathogen-enriched protein families putatively secreted by type II secretory system: PheA (CM-sec), LipA/LesA, VirK, and four families involved in N-glycan degradation, NixE, NixF, NixL, and FucA1. In silico and phylogenetic analyses of these protein families revealed they all have orthologs in other phytopathogenic or symbiotic bacteria, and are involved in the modulation and evasion of the immune system. As a proof of concept, we performed a biochemical characterization of LipA from Xac306 and verified that the mutant strain lost most of its lipase and esterase activities and displayed reduced virulence in citrus. Since this study includes closely related organisms with distinct lifestyles and highlights proteins directly related to adaptation inside plant tissues, novel approaches might use these proteins as biotechnological targets for disease control, and contribute to our understanding of the coevolution of plant-associated bacteria.
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