Evidence map›Paper›PMID 29170472›Full record

ArticleScientific reports2017

Interaction Effects of AFB1 and MC-LR Co-exposure with Polymorphism of Metabolic Genes on Liver Damage: focusing on SLCO1B1 and GSTP1.

Xiaohong Yang, Wenyi Liu, Hui Lin, Hui Zeng, Renping Zhang, Chaowen Pu, Lingqiao Wang, Chuanfen Zheng, Yao Tan, Yang Luo and 11 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Risk assessment of aflatoxins in food.EFSA journal. European Food Safety Authority · 2020
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 3 institutions in 1 country.

Xiaohong YangDepartment of Environmental Hygiene, College of Preventive Medicine, Third Military Medical University, Chongqing, 400038, China.
Wenyi LiuDepartment of Environmental Hygiene, College of Preventive Medicine, Third Military Medical University, Chongqing, 400038, China.
Hui LinDepartment of Tropical Epidemiology, College of Preventive Medicine, Third Military Medical University, Chongqing, 400038, China.
Hui ZengDepartment of Environmental Hygiene, College of Preventive Medicine, Third Military Medical University, Chongqing, 400038, China.
Renping ZhangThe Center for Disease Control and Prevention in Fuling District, Chongqing, 408000, China.
Chaowen PuThe Center for Disease Control and Prevention in Fuling District, Chongqing, 408000, China.
Lingqiao WangDepartment of Environmental Hygiene, College of Preventive Medicine, Third Military Medical University, Chongqing, 400038, China.
Chuanfen ZhengDepartment of Environmental Hygiene, College of Preventive Medicine, Third Military Medical University, Chongqing, 400038, China.
Yao TanDepartment of Environmental Hygiene, College of Preventive Medicine, Third Military Medical University, Chongqing, 400038, China.
Yang LuoCenter for Nanomedicine, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China.
Xiaobin FengInstitute of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China.
Yingqiao TianThe Center for Disease Control and Prevention in Fuling District, Chongqing, 408000, China.
Guosheng XiaoCollege of Life Science and Engineering, Chongqing Three Gorges University, Wanzhou, Chongqing, 404100, China.
Jia WangDepartment of Environmental Hygiene, College of Preventive Medicine, Third Military Medical University, Chongqing, 400038, China.
Yujing HuangDepartment of Environmental Hygiene, College of Preventive Medicine, Third Military Medical University, Chongqing, 400038, China.
Jiaohua LuoDepartment of Environmental Hygiene, College of Preventive Medicine, Third Military Medical University, Chongqing, 400038, China.
Zhiqun QiuDepartment of Environmental Hygiene, College of Preventive Medicine, Third Military Medical University, Chongqing, 400038, China.
Ji-An ChenDepartment of Health Education, College of Preventive Medicine, Third Military Medical University, Chongqing, 400038, China.
Liping WuDepartment of Environmental Hygiene, College of Preventive Medicine, Third Military Medical University, Chongqing, 400038, China.
Lixiong HeDepartment of Environmental Hygiene, College of Preventive Medicine, Third Military Medical University, Chongqing, 400038, China.
Weiqun ShuDepartment of Environmental Hygiene, College of Preventive Medicine, Third Military Medical University, Chongqing, 400038, China. xm0630@sina.com.ORCID 0000-0003-4762-098X
Army Medical University · CNFuling Center Hospital of Chongqing · CNChongqing Three Gorges University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

AFB1 and MC-LR are two major environmental risk factors for liver damage worldwide, especially in warm and humid areas, but there are individual differences in health response of the toxin-exposed populations. Therefore, we intended to identify the susceptible genes in transport and metabolic process of AFB1 and MC-LR and find their effects on liver damage. We selected eight related SNPs that may affect liver damage outcomes in AFB1 and MC-LR exposed persons, and enrolled 475 cases with liver damage and 475 controls of healthy people in rural areas of China. The eight SNPs were genotyped by PCR and restriction fragment length polymorphism. We found that SLCO1B1 (T521C) is a risk factor for liver damage among people exposed to high AFB1 levels alone or combined with MC-LR, and that GSTP1 (A1578G) could indicate the risk of liver damage among those exposed to high MC-LR levels alone or combined with high AFB1 levels. However, GSTP1 (A1578G) could reduce the risk of liver damage in populations exposed to low MC-LR levels alone or combined with high AFB1 levels. In conclusion, SLCO1B1 (T521C) and GSTP1 (A1578G) are susceptible genes for liver damage in humans exposed to AFB1 and/or MC-LR in rural areas of China.

Indexed as

Aflatoxin B1AgedChemical and Drug Induced Liver InjuryFemaleGlutathione S-Transferase piHumansLiver-Specific Organic Anion Transporter 1MaleMarine ToxinsMicrocystinsMiddle AgedPolymorphism, GeneticRisk FactorsAflatoxin B1cyanoginosin LRGlutathione S-Transferase piLiver-Specific Organic Anion Transporter 1Marine ToxinsMicrocystinsSLCO1B1 protein, human

Identifiers

PMID29170472
PMCPMC5700940
OpenAlexW2769749600

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.