Evidence map›Paper›PMID 29170471›Full record

ArticleNature reviews. Drug discovery2018

Steps forward for cancer precision medicine.

Roberto Salgado, Helen Moore, John W M Martens, Tracy Lively, Shakun Malik, Ultan McDermott, Stefan Michiels, Jeffrey A Moscow, Sabine Tejpar, Tawnya McKee and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature reviews. Drug discovery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Information, communication, and cancer patients' trust in the physician: what challenges do we have to face in an era of precision cancer medicine?Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Repositioning Lidocaine as an Anticancer Drug: The Role Beyond Anesthesia.Frontiers in cell and developmental biology · 2020
    Review
  14. Article
  15. CMTTdb: the cancer molecular targeted therapy database.Annals of translational medicine · 2019
    Article
  16. Review
  17. Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2019
    Article
  18. Engineering Precision Medicine.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Roberto SalgadoDepartment of Pathology, Gasthuiszusters Antwerpen, Antwerp, Belgium.
Helen MooreBiorepositories and Biospecimen Research Branch; Division of Cancer Treatment and Diagnosis (DCTD); Cancer Therapy Evaluation Program; DCTD and Investigational Drug Branch; DCTD; NCI, NIH, Bethesda, Maryland, USA.
John W M MartensErasmus MC Cancer Institute and Cancer Genomics Netherlands, Erasmus University Medical Center, Rotterdam, The Netherlands.
Tracy LivelyBiorepositories and Biospecimen Research Branch; Division of Cancer Treatment and Diagnosis (DCTD); Cancer Therapy Evaluation Program; DCTD and Investigational Drug Branch; DCTD; NCI, NIH, Bethesda, Maryland, USA.
Shakun MalikBiorepositories and Biospecimen Research Branch; Division of Cancer Treatment and Diagnosis (DCTD); Cancer Therapy Evaluation Program; DCTD and Investigational Drug Branch; DCTD; NCI, NIH, Bethesda, Maryland, USA.
Ultan McDermottWellcome Trust Sanger Institute, Cambridge, UK.
Stefan MichielsINSERM, University Paris-Sud, Univerisity Paris Saclay, Villejuif, France.
Jeffrey A MoscowBiorepositories and Biospecimen Research Branch; Division of Cancer Treatment and Diagnosis (DCTD); Cancer Therapy Evaluation Program; DCTD and Investigational Drug Branch; DCTD; NCI, NIH, Bethesda, Maryland, USA.
Sabine TejparUniversity Hospital Gasthuisberg, Leuven, Belgium.
Tawnya McKeeBiorepositories and Biospecimen Research Branch; Division of Cancer Treatment and Diagnosis (DCTD); Cancer Therapy Evaluation Program; DCTD and Investigational Drug Branch; DCTD; NCI, NIH, Bethesda, Maryland, USA.
Denis LacombeEORTC Headquarters, 1200 Brussels, Belgium.
IBCD-Faculty

Funding

Metabolic characterization of FH- and SDH-deficient RCC cell linesZIABC011701 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI MOSCOW, JEFFREY · 2016 to 2019
$550k
6 · The paper itself

Abstract

The availability of targeted anticancer drugs and the relative affordability of genomic analyses has led to a growing expectation among patients with cancer that they can receive personalized treatment based on the genomic signature of their tumour. Here, we discuss some of the challenges and steps needed to bring such approaches into routine practice.

Indexed as

Biomarkers, TumorAntineoplastic AgentsCongresses as TopicDrug DesignGenome-Wide Association StudyHumansMolecular Targeted TherapyNeoplasmsPrecision MedicineAntineoplastic AgentsBiomarkers, Tumor

Identifiers

PMID29170471

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.