ArticleAJNR. American journal of neuroradiology2018
Perivascular Spaces in Old Age: Assessment, Distribution, and Correlation with White Matter Hyperintensities.
Article in AJNR. American journal of neuroradiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 65 citations in OpenAlex.
- Vascular drivers of cerebrospinal fluid movement and enlarged perivascular spaces.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Large-scale neural slowing measured with electroencephalography indexes secondary thalamic degeneration in stroke.medRxiv : the preprint server for health sciences · 2026Article
- Comparison of the Radiomics Features of Normal-Appearing White Matter in Persons with High or Low Perivascular Space Scores.Journal of imaging · 2026Article
- Leptomeninges: Anatomy, Mechanisms of Disease and Neuroimaging.Neurology international · 2025Review
- Subcortical brain volumetric differences related to white matter lesion volume and cognition in healthy aging.npj aging · 2025Article
- A window into the brain: multimodal MRI assessment of vascular cognitive impairment.Frontiers in neuroscience · 2025Review
- Clinical Relevance of Different Loads of Perivascular Spaces According to Their Localization in Patients with a Recent Small Subcortical Infarct.Journal of cardiovascular development and disease · 2024Article
- Deep-learning-based segmentation of perivascular spaces on T2-Weighted 3T magnetic resonance images.Frontiers in aging neuroscience · 2024Article
- Enlarged Perivascular Space and Index for Diffusivity Along the Perivascular Space as Emerging Neuroimaging Biomarkers of Neurological Diseases.Cellular and molecular neurobiology · 2023Review
- Imaging the neurovascular unit in health and neurodegeneration: a scoping review of interdependencies between MRI measures.Fluids and barriers of the CNS · 2023Article
- Brain perivascular space imaging across the human lifespan.NeuroImage · 2023Article
- Effect of cerebral small vessel disease on cognitive impairment in Parkinson's disease.Acta neurologica Belgica · 2023Article
- White Matter Hyperintensities in Young Patients from a Neurological Outpatient Clinic: Prevalence, Risk Factors, and Correlation with Enlarged Perivascular Spaces.Journal of personalized medicine · 2023Article
- Arterial spin labeling signal in the CSF: Implications for partial volume correction and blood-CSF barrier characterization.NMR in biomedicine · 2023Article
- Association Between Behavioral, Biological, and Genetic Markers of Cardiovascular Health and MRI Markers of Brain Aging: A Cohort Study.Neurology · 2023Article
- Postmortem Brain Imaging in Alzheimer's Disease and Related Dementias: The South Texas Alzheimer's Disease Research Center Repository.Journal of Alzheimer's disease : JAD · 2023Article
- Automated Methods for Detecting and Quantitation of Enlarged Perivascular spaces on MRI.Journal of magnetic resonance imaging : JMRI · 2023Review
- Understanding Immune-Driven Brain Aging by Human Brain Organoid Microphysiological Analysis Platform.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Association of Dilated Perivascular Spaces With Lipid Indices in Ischemic Stroke Patients.Cureus · 2022Article
- Imaging perivascular space structure and function using brain MRI.NeuroImage · 2022Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeThe visual rating scales for perivascular spaces vary considerably. We sought to develop a new scale for visual assessment of perivascular spaces and to further describe their distribution and association with white matter hyperintensities in old age. MATERIALS AND
methodsThis population-based study included 530 individuals who did not have dementia and were not institutionalized (age, ≥60 years or older; mean age, 70.7 years; 58.9% women) who were living in central Stockholm, Sweden. A semiquantitative visual rating scale was developed to score the number and size of visible perivascular spaces in 7 brain regions in each hemisphere. A modified Scheltens visual rating scale was used to assess white matter hyperintensities.
resultsThe global scores for perivascular spaces ranged from 4-32 for number, 3-22 for size, and 7-54 for the combination of number and size. The weighted κ statistics for the intra- and interrater reliability both were 0.77. The global score for the number of perivascular spaces increased with advancing age (
conclusionsThe new visual rating scale for perivascular spaces shows excellent intra- and interrater reliability. The number of perivascular spaces globally and, especially, in the basal ganglia, is correlated with the load of lobar and deep white matter hyperintensities, supporting the view that perivascular spaces are a marker for cerebral small-vessel disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.