Evidence map›Paper›PMID 29170152›Full record

ArticleCirculation2018

Impact of Lipid Measurements in Youth in Addition to Conventional Clinic-Based Risk Factors on Predicting Preclinical Atherosclerosis in Adulthood: International Childhood Cardiovascular Cohort Consortium.

Juha Koskinen, Markus Juonala, Terence Dwyer, Alison Venn, Russell Thomson, Lydia Bazzano, Gerald S Berenson, Matthew A Sabin, Trudy L Burns, Jorma S A Viikari and 10 more

Registry-linked trialOpen access · bronzeAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00005129 (The Bogalusa Heart Study), which is not on this map. Cited by 46 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 2 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00005129 active not recruitingnot on this map

The Bogalusa Heart Study

TypeobservationalSponsorTulane UniversityRan1973 to 2029Enrolled11,737ConditionsAtherosclerosis, Cardiovascular Diseases, Heart Diseases, Coronary Disease
3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 2 syntheses or guidelines pooled it, 81 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Gender diversity and cholesterol in early adolescence: Findings from the Adolescent Brain Cognitive Development Study.International journal of cardiology. Cardiovascular risk and prevention · 2026
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  13. Childhood obesity: The threatening apprentice of the adiposity empire.Reviews in endocrine & metabolic disorders · 2025
    Review
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  15. Article
  16. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors at 14 institutions in 5 countries.

Juha KoskinenResearch Center of Applied and Preventive Cardiovascular Medicine (J.K., O.T.R., C.G.M.) jkkosk@utu.fi.
Markus JuonalaDepartment of Medicine (M.J., J.S.A.V.), University of Turku, Finland.
Terence DwyerGeorge Institute, University of Oxford, United Kingdom (T.D.).
Alison VennMenzies Institute for Medical Research, University of Tasmania, Hobart, Australia (T.D., A.V., C.G.M.).
Russell ThomsonCentre for Research in Mathematics, School of Computing, Engineering and Mathematics, Western Sydney University, Australia (R.T.).
Lydia BazzanoDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA (L.B., G.S.B.).
Gerald S BerensonDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA (L.B., G.S.B.).
Matthew A SabinMurdoch Children's Research Institute, The Royal Children's Hospital and University of Melbourne, Australia (M.A.S.).
Trudy L BurnsDepartment of Epidemiology, College of Public Health, University of Iowa, Iowa City (T.L.B.).
Jorma S A ViikariDepartment of Medicine (M.J., J.S.A.V.), University of Turku, Finland.
Jessica G WooDepartment of Pediatrics, Division of Biostatistics and Epidemiology (J.G.W.).
Elaine M UrbinaDepartment of Pediatrics, Division of Cardiology (E.M.U.), Cincinnati Children's Hospital Medical Center and University of Cincinnati, OH.
Ronald PrineasDivision of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC (R.P.).
Nina Hutri-KähönenDepartment of Pediatrics, University of Tampere School of Medicine and Tampere University Hospital, Finland (N.H.-K.).
Alan SinaikoDepartment of Pediatrics (A.S., J.S.).
David JacobsDivision of Epidemiology and Community Health (D.J.), University of Minnesota, Minneapolis.
Julia SteinbergerDepartment of Pediatrics (A.S., J.S.).
Stephen DanielsDepartment of Pediatrics, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora (S.D.).
Olli T RaitakariResearch Center of Applied and Preventive Cardiovascular Medicine (J.K., O.T.R., C.G.M.).
Costan G MagnussenResearch Center of Applied and Preventive Cardiovascular Medicine (J.K., O.T.R., C.G.M.).
University of Tasmania · AUTulane University · USUniversity of Turku · FICincinnati Children's Hospital Medical Center · USMurdoch Children's Research Institute · AUSteinhauser (Czechia) · CZTampere University Hospital · FITurku University Hospital · FIUniversity of Cincinnati · USUniversity of Colorado Denver · USUniversity of Iowa · USUniversity of Minnesota · USWake Forest University · USWestern Sydney University · AU

Funding

Childhood CV Risk and Adult CVD Outcomes: an International Long-term Follow-upR01HL121230 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI BURNS, TRUDY L, CHEN, WEI · 2015 to 2019
$13.3M
Lifespan Cardiovascular Risk Exposures and Alzheimer-related brain health: Bogalusa Heart StudyRF1AG041200 · NIA · TULANE UNIVERSITY OF LOUISIANA · PI BAZZANO, LYDIA, CARMICHAEL, OWEN T. · 2019 to 2022
$4.2M
The Role of Vascular Aging in Cognitive and Physical Function - Diversity SupplementR01AG041200 · NIA · TULANE UNIVERSITY OF LOUISIANA · PI BAZZANO, LYDIA · 2012 to 2017
$2.9M
NHLBI NIH HHS R01 HL121230NIA NIH HHS RF1 AG041200
6 · The paper itself

Abstract

backgroundData suggest that the prediction of adult cardiovascular disease using a model comprised entirely of adult nonlaboratory-based risk factors is equivalent to an approach that additionally incorporates adult lipid measures. We assessed and compared the utility of a risk model based solely on nonlaboratory risk factors in adolescence versus a lipid model based on nonlaboratory risk factors plus lipids for predicting high-risk carotid intima-media thickness (cIMT) in adulthood.

methodsThe study comprised 2893 participants 12 to 18 years of age from 4 longitudinal cohort studies from the United States (Bogalusa Heart Study and the Insulin Study), Australia (Childhood Determinants of Adult Health Study), and Finland (The Cardiovascular Risk in Young Finns Study) and followed into adulthood when cIMT was measured (mean follow-up, 23.4 years). Overweight status was defined according to the Cole classification. Hypertension was defined according to the Fourth Report on High Blood Pressure in Children and Adolescents from the National High Blood Pressure Education Program. High-risk plasma lipid levels were defined according to the National Cholesterol Education Program Expert Panel on Cholesterol Levels in Children. High cIMT was defined as a study-specific value ≥90th percentile. Age and sex were included in each model.

resultsIn univariate models, all risk factors except for borderline high and high triglycerides in adolescence were associated with high cIMT in adulthood. In multivariable models (relative risk [95% confidence interval]), male sex (2.7 [2.0-2.6]), prehypertension (1.4 [1.0-1.9]), hypertension (1.9 [1.3-2.9]), overweight (2.0 [1.4-2.9]), obesity (3.7 [2.0-7.0]), borderline high low-density lipoprotein cholesterol (1.6 [1.2-2.2]), high low-density lipoprotein cholesterol (1.6 [1.1-2.1]), and borderline low high-density lipoprotein cholesterol (1.4 [1.0-1.8]) remained significant predictors of high cIMT (

conclusionsNonlaboratory-based risk factors and lipids measured in adolescence independently predicted preclinical atherosclerosis in young adulthood. The addition of lipid measurements to traditional clinic-based risk factor assessment provided a statistically significant but clinically modest improvement on adolescent prediction of high cIMT in adulthood.

Indexed as

AdolescentAdultAge of OnsetAsymptomatic DiseasesAustraliaBiomarkersCarotid Artery DiseasesCarotid Intima-Media ThicknessChildDyslipidemiasFemaleFinlandHumansHypertensionLipidsMaleBiomarkersLipidsintima-media thicknesslipidsrisk prediction

Identifiers

PMID29170152
PMCPMC5860965
OpenAlexW2768226150

What OpenQuestion holds

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LicenceTDM
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.