Evidence map›Paper›PMID 29170050›Full record

ArticlePancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]2018

Identification of a pyruvate-to-lactate signature in pancreatic intraductal papillary mucinous neoplasms.

Alan R Penheiter, Dinesh K Deelchand, Emily Kittelson, Sibel Erdogan Damgard, Stephen J Murphy, Daniel R O'Brien, William R Bamlet, Marie R Passow, Thomas C Smyrk, Fergus J Couch and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Quantitative pancreatic MRI: a pathology-based review.The British journal of radiology · 2019
    Review
  5. Targeting tumor-associated acidity in cancer immunotherapy.Cancer immunology, immunotherapy : CII · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Alan R PenheiterDepartment of Molecular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
Dinesh K DeelchandCenter for Magnetic Resonance Research and Department of Radiology, University of Minnesota, 2021 6th Street SE, Minneapolis, MN 55455, USA.
Emily KittelsonCenter for Magnetic Resonance Research and Department of Radiology, University of Minnesota, 2021 6th Street SE, Minneapolis, MN 55455, USA.
Sibel Erdogan DamgardDepartment of Biochemistry and Molecular Biology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
Stephen J MurphyDepartment of Molecular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
Daniel R O'BrienDepartment of Health Science Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
William R BamletDepartment of Health Science Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
Marie R PassowDepartment of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
Thomas C SmyrkDepartment of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
Fergus J CouchDepartment of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
George VasmatzisDepartment of Molecular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
John D PortDepartment of Radiology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
Małgorzata MarjańskaCenter for Magnetic Resonance Research and Department of Radiology, University of Minnesota, 2021 6th Street SE, Minneapolis, MN 55455, USA.
Stephanie K CarlsonDepartment of Molecular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA; Department of Radiology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. Electronic address: scarlson@mayo.edu.
Mayo Clinic · USResonance Research (United States) · USUniversity of Minnesota · US

Funding

Mayo Clinic Center for Translational Science ActivitiesUL1TR000135 · NCATS · MAYO CLINIC ROCHESTER · PI KHOSLA, SUNDEEP · 2012 to 2015
$41.2M
Tissue CoreP50CA102701 · NCI · MAYO CLINIC ROCHESTER · PI BILLADEAU, DANIEL D, PETERSEN, GLORIA M. · 2004 to 2018
$32.7M
NMR Imaging and SpectroscopyP41EB015894 · NIBIB · UNIVERSITY OF MINNESOTA · PI UGURBIL, KAMIL · 2012 to 2017
$8.4M
NCI NIH HHS P50 CA102701NIBIB NIH HHS P41 EB015894
6 · The paper itself

Abstract

objectiveWe used transcriptomic profiling and immunohistochemistry (IHC) to search for a functional imaging strategy to resolve common problems with morphological imaging of cystic neoplasms and benign cystic lesions of the pancreas.

methodsResected pancreatic cancer (n = 21) and normal pancreas were laser-capture micro-dissected, and transcripts were quantified by RNAseq. Functional imaging targets were validated at the protein level by IHC on a pancreatic adenocarcinoma tissue microarray and a newly created tissue microarray of resected intraductal papillary mucinous neoplasms (IPMNs) and IPMN-associated adenocarcinomas.

resultsGenes encoding proteins responsible for cellular import of pyruvate, export of lactate, and conversion of pyruvate to lactate were highly upregulated in pancreatic adenocarcinoma compared to normal pancreas. Strong expression of MCT4 and LDHA was observed by IHC in >90% of adenocarcinoma specimens. In IPMNs, the pyruvate-to-lactate signature was significantly elevated in high grade dysplasia (HGD) and IPMN-associated adenocarcinoma. Additionally, cores containing HGD and/or adenocarcinoma exhibited a higher number of peri-lesional stromal cells and a significant increase in peri-lesional stromal cell staining of LDHA and MCT4. Interestingly, the pyruvate-to-lactate signature was significantly upregulated in cores containing only low grade dysplasia (LGD) from patients with histologically confirmed IPMN-associated adenocarcinoma versus LGD cores from patients with non-invasive IPMNs.

conclusionOur results suggest prospective studies with hyperpolarized [1-

Indexed as

Adenocarcinoma, MucinousBiomarkers, TumorCarcinoma, Pancreatic DuctalCarcinoma, PapillaryGene Expression Regulation, NeoplasticHumansLactic AcidPancreasPancreatic NeoplasmsPyruvic AcidRetrospective StudiesTranscriptomeBiomarkers, TumorLactic AcidPyruvic AcidHyperpolarizedIPMNMagnetic resonance spectroscopyPancreatic adenocarcinomaPyruvate

Identifiers

PMID29170050
PMCPMC6139027
OpenAlexW2768430380

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.