Evidence map›Paper›PMID 29169634›Full record

ReviewTrends in neurosciences2018

The Emerging Neurobiology of Bipolar Disorder.

Paul J Harrison, John R Geddes, Elizabeth M Tunbridge

Registry-linked trialOpen access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Trends in neurosciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07785167 (Characterization of Chemokine Receptor Expression in CD8+ T Lymphocytes in Bipolar Disorder), which is not on this map. Cited by 117 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
117citing papers in PubMed, 8 pooled it
13.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07785167 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Characterization of Chemokine Receptor Expression in CD8+ T Lymphocytes in Bipolar Disorder

TypeobservationalSponsorUniversity of CataniaRan2026 to 2028Enrolled172ConditionsBipolar Affective DisordersArmsCD8+ T-Cell Gene Expression Analysis
3 · Its place in the literature

Who cites it

117 citing papers in PubMed, 8 syntheses or guidelines pooled it, 224 citations in OpenAlex.

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57 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Paul J HarrisonDepartment of Psychiatry, University of Oxford, Warneford Hospital, Oxford, OX3 7JX, UK; Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford, OX3 7JX, UK. Electronic address: paul.harrison@psych.ox.ac.uk.
John R GeddesDepartment of Psychiatry, University of Oxford, Warneford Hospital, Oxford, OX3 7JX, UK; Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford, OX3 7JX, UK.
Elizabeth M TunbridgeDepartment of Psychiatry, University of Oxford, Warneford Hospital, Oxford, OX3 7JX, UK; Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford, OX3 7JX, UK.
Oxford Health NHS Foundation Trust · GBUniversity of Oxford · GB

Funding

Medical Research Council MR/P026028/1Medical Research Council P026028/1Wellcome TrustWellcome Trust 09846Wellcome Trust 102616
6 · The paper itself

Abstract

Bipolar disorder (BD) is a leading cause of global disability. Its biological basis is unknown, and its treatment unsatisfactory. Here, we review two recent areas of progress. First, the discovery of risk genes and their implications, with a focus on voltage-gated calcium channels as part of the disease process and as a drug target. Second, facilitated by new technologies, it is increasingly apparent that the bipolar phenotype is more complex and nuanced than simply one of recurring manic and depressive episodes. One such feature is persistent mood instability, and efforts are underway to understand its mechanisms and its therapeutic potential. BD illustrates how psychiatry is being transformed by contemporary neuroscience, genomics, and digital approaches.

Indexed as

AnimalsBipolar DisorderHumansdigital phenotypinggenomicsL-type calcium channelsmood disordermood instabilitytherapeutics

Identifiers

PMID29169634
PMCPMC5755726
OpenAlexW2770518716

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.