ArticleUltrasonography (Seoul, Korea)2018
Ultrasonographic features of pure ductal carcinoma in situ of the breast: correlations with pathologic features and biological markers.
Article in Ultrasonography (Seoul, Korea), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- Imaging Ductal Carcinoma In Situ in the Era of De-Escalation: Role, Limits, and Clinical Implications for Risk-Adapted Management.Diagnostics (Basel, Switzerland) · 2026Review
- An update on multimodal imaging strategies for nipple discharge: from detection to decision.Insights into imaging · 2025Article
- [Ultrasound Multimodality Examination Improves the Diagnostic Efficiency of Non-Mass-Like Breast Lesions].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2024Article
- Ultrasound deep learning radiomics and clinical machine learning models to predict low nuclear grade, ER, PR, and HER2 receptor status in pure ductal carcinomaGland surgery · 2024Article
- Multimodal Machine Learning-Based Ductal Carcinoma in situ Prediction from Breast Fibromatosis.Cancer management and research · 2024Article
- High-Grade Ductal CarcinomaEuropean journal of breast health · 2023Article
- The diagnostic value of contrast-enhanced ultrasonography in breast ductal abnormalities.Cancer imaging : the official publication of the International Cancer Imaging Society · 2023Article
- Elasticity of leg muscles and incidence of falls in older adults: a prospective cohort analysis.European geriatric medicine · 2023Article
- Ultrasound evaluation of ductal carcinoma in situ of the breast.Journal of ultrasound · 2022Article
- Comparison of ultrasonographic and mammographic features of extremely rare papillary carcinoma and invasive ductal carcinoma.Contemporary oncology (Poznan, Poland) · 2022Article
- Ultrasonographic features of ductal carcinoma in situ: analysis of 219 lesions.Gland surgery · 2020Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
purposeThe purpose of this study was to evaluate the ultrasonographic features of pure ductal carcinoma in situ (DCIS) of the breast and to evaluate the correlations of ultrasonographic features with pathologic and biological features.
methodsA total of 141 lesions in 138 women with pure DCIS who underwent preoperative breast ultrasonography were retrospectively reviewed. Ultrasonographic features were analyzed using the American College of Radiology Breast Imaging Reporting and Data System (BI-RADS) ultrasonography lexicon and the diagnostic criteria of the Japan Society of Ultrasonics in Medicine. Pathologic features including the nuclear grade and presence of comedonecrosis were evaluated. Biological markers including estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) status, as well as the Ki-67 index, were recorded. Ultrasonographic features were compared with pathologic findings and biological markers using the chi-square test. P-values of <0.05 were considered to indicate statistical significance.
resultsOf the 141 lesions, 75 (53.2%) were mass lesions, 26 (39.7%) were non-mass lesions, and 10 (7.1%) were not visible. The most common feature of the mass pattern was a mass with irregular shape (32.6%), an indistinct margin (27.7%), and hypoechogenicity (37.6%). Microcalcifications were observed in 48 cases (36.6%) as an associated feature. Calcifications outside of a mass were more common than calcifications within a mass. Ultrasonographic microcalcifications and ductal changes were frequently observed in non-mass lesions. Ultrasonographic non-mass lesions were associated with high-grade DCIS (P=0.004) and the presence of comedonecrosis (P=0.006), and microcalcifications were significantly associated with high-grade DCIS, the presence of comedonecrosis, an elevated Ki-67 index (P<0.001 for all), and HER2 positivity (P=0.003).
conclusionThe most common ultrasonographic feature of pure DCIS was an irregular, hypoechoic mass with an indistinct margin. Ultrasonographic microcalcifications and ductal changes were more frequent in non-mass lesions, which were correlated with poor prognostic factors, such as a high nuclear grade, comedonecrosis, HER2 positivity, and an elevated Ki-67 index.
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