Evidence map›Paper›PMID 29168922›Full record

ReviewThe British journal of radiology2018

Focused ultrasound: tumour ablation and its potential to enhance immunological therapy to cancer.

Giovanni Mauri, Luca Nicosia, Zhen Xu, Salvatore Di Pietro, Lorenzo Monfardini, Guido Bonomo, Gianluca Maria Varano, Francesco Prada, Paolo Della Vigna, Franco Orsi

Abstract readReview
In one paragraph

Review in The British journal of radiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  6. Observational
  7. Overview of Therapeutic Ultrasound Applications and Safety Considerations: 2024 Update.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Giovanni Mauri1 Deparmtent of interventional radiology, European istitute of oncology , Milan , Italy.
Luca Nicosia2 Postgraduate School of Radiology, Università degli Studi di Milano , Milan , Italy.
Zhen Xu3 Department of Biomedical Engineering, University of Michigan , Ann Arbor, MI , USA.
Salvatore Di Pietro2 Postgraduate School of Radiology, Università degli Studi di Milano , Milan , Italy.
Lorenzo Monfardini4 Department of Radiology and diagnotic imaging, Poliambulazna di Brescia , Brescia , Italy.
Guido Bonomo1 Deparmtent of interventional radiology, European istitute of oncology , Milan , Italy.
Gianluca Maria Varano1 Deparmtent of interventional radiology, European istitute of oncology , Milan , Italy.
Francesco Prada5 Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico Carlo Besta , Milan , Italy.
Paolo Della Vigna1 Deparmtent of interventional radiology, European istitute of oncology , Milan , Italy.
Franco Orsi1 Deparmtent of interventional radiology, European istitute of oncology , Milan , Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Various kinds of image-guided techniques have been successfully applied in the last years for the treatment of tumours, as alternative to surgical resection. High intensity focused ultrasound (HIFU) is a novel, totally non-invasive, image-guided technique that allows for achieving tissue destruction with the application of focused ultrasound at high intensity. This technique has been successfully applied for the treatment of a large variety of diseases, including oncological and non-oncological diseases. One of the most fascinating aspects of image-guided ablations, and particularly of HIFU, is the reported possibility of determining a sort of stimulation of the immune system, with an unexpected "systemic" response to treatments designed to be "local". In the present article the mechanisms of action of HIFU are described, and the main clinical applications of this technique are reported, with a particular focus on the immune-stimulation process that might originate from tumour ablations.

Indexed as

Ultrasonography, InterventionalHigh-Intensity Focused Ultrasound AblationHumansImmunotherapyNeoplasms

Identifiers

PMID29168922
PMCPMC5965486

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.