Evidence map›Paper›PMID 29168740›Full record

ArticleInternational journal of environmental research and public health2017

Dietary Intake of Cadmium, Lead and Mercury and Its Association with Bone Health in Healthy Premenopausal Women.

Jesus M Lavado-García, Luis M Puerto-Parejo, Raul Roncero-Martín, Jose M Moran, Juan D Pedrera-Zamorano, Ignacio J Aliaga, Olga Leal-Hernández, Maria L Canal-Macias

Open access · goldAbstract read
In one paragraph

Article in International journal of environmental research and public health, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. Exposure to heavy metals and the risk of osteopenia or osteoporosis: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2020
    Pooled it
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  4. Bone morphogenetic protein 4 is involved in cadmium-associated bone damage.Toxicological sciences : an official journal of the Society of Toxicology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Jesus M Lavado-GarcíaMetabolic Bone Diseases Research Group, Nursing Department, University of Extremadura, 10003 Cáceres, Spain. jmlavado@unex.es.
Luis M Puerto-ParejoMetabolic Bone Diseases Research Group, Nursing Department, University of Extremadura, 10003 Cáceres, Spain. lmpuerto@unex.es.
Raul Roncero-MartínMetabolic Bone Diseases Research Group, Nursing Department, University of Extremadura, 10003 Cáceres, Spain. rronmar@unex.es.
Jose M MoranMetabolic Bone Diseases Research Group, Nursing Department, University of Extremadura, 10003 Cáceres, Spain. jmmorang@unex.es.
Juan D Pedrera-ZamoranoMetabolic Bone Diseases Research Group, Nursing Department, University of Extremadura, 10003 Cáceres, Spain. jpedrera@unex.es.
Ignacio J AliagaMetabolic Bone Diseases Research Group, Nursing Department, University of Extremadura, 10003 Cáceres, Spain. i.aliaga@pdi.ucm.es.
Olga Leal-HernándezMetabolic Bone Diseases Research Group, Nursing Department, University of Extremadura, 10003 Cáceres, Spain. olgaleal@unex.es.
Maria L Canal-MaciasMetabolic Bone Diseases Research Group, Nursing Department, University of Extremadura, 10003 Cáceres, Spain. luzcanal@unex.es.
Universidad de Extremadura · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The bone is one of the relevant target organs of heavy metals, and heavy metal toxicity is associated with several degenerative processes, such osteoporosis and bone mineral alterations, that could lead to fractures. We aimed to study a presumed relationship between bone density, evaluated by quantitative bone ultrasound (QUS), dual-energy X-ray absorptiometry (DXA) and peripheral quantitative computed tomography (pQCT) and the dietary intake of cadmium, lead and mercury in healthy premenopausal women. A total of 158 healthy, non-smoking, premenopausal women were incorporated into the study. A validated food frequency questionnaire (FFQ) was administered to assess intake during the preceding seven days. The median predicted dietary cadmium intake among the 158 women studied was 25.29 μg/day (18.62-35.00) and 2.74 μg/kg body weight/week (b.w./w) (1.92-3.83). Dietary lead intake was 43.85 μg/day (35.09-51.45) and 4.82 μg/kg b.w./w (3.67-6.13). The observed dietary mercury intake was 9.55 μg/day (7.18-13.57) and 1.02 μg/kg b.w./w (0.71-1.48). Comparisons, in terms of heavy metal intake, showed no significant results after further adjusting for energy intake. No statistically significant correlations between heavy metal intake and the QUS, DXA and pQCT parameters were observed. Levels of dietary exposure of cadmium, lead and mercury were mostly within the recommendations. We did not find associations between the QUS, DXA and pQCT parameters and the dietary intake of the studied heavy metals in healthy premenopausal women.

Indexed as

DietAbsorptiometry, PhotonAdultBone and BonesBone DensityCadmiumFemaleHumansLeadMercuryMetals, HeavyOsteoporosisPremenopauseTomography, X-Ray ComputedUltrasonographyWomen's HealthCadmiumLeadMercuryMetals, Heavybone healthbone mineral densitydietary intakefoodheavy metalspremenopausewomen’s health

Identifiers

PMID29168740
PMCPMC5750856
OpenAlexW2771025798

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.