Evidence map›Paper›PMID 29168629›Full record

ArticleJournal of cachexia, sarcopenia and muscle2017

Myostatin and beyond in cirrhosis: all roads lead to sarcopenia.

Srinivasan Dasarathy

Open access · goldAbstract readEditorialComment
In one paragraph

Article in Journal of cachexia, sarcopenia and muscle, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 75 citations in OpenAlex.

  1. Trial
  2. Trial
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  4. Article
  5. Article
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  7. Article
  8. [Assessment and management of malnutrition in patients with cirrhosis combined with hepatic encephalopathy].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2025
    Review
  9. The Role of Myokines in Liver Diseases.International journal of molecular sciences · 2025
    Review
  10. Article
  11. Bedside assessment of sarcopenia in hospitalized patients with liver cirrhosis: Magnitude and clinical implications.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2024
    Article
  12. Ammonia transporter RhBG initiates downstream signaling and functional responses by activating NFκB.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. [Sarcopenia in Chronic Liver Disease].The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2023
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Srinivasan DasarathyProfessor of Medicine, Cleveland Clinic Lerner College of Medicine; Director, Liver Metabolism Research; Staff, Departments of Gastroenterology, Hepatology and Pathobiology, Cleveland Clinic, Cleveland, OH, USA.
Cleveland Clinic Lerner College of Medicine · US

Funding

Project Two - Exercise Training Decreases Alcohol Drinking by an FGF21-Dependent MechanismP50AA024333 · NIAAA · CLEVELAND CLINIC LERNER COM-CWRU · PI Thomas M McIntyre · 2016 to 2026
$19.6M
Non Alcoholic Steatohepatitis Clinical Research NetworkU01DK061732 · NIDDK · CLEVELAND CLINIC LERNER COM-CWRU · PI Srinivasan Dasarathy · 2002 to 2026
$12.2M
Mechanisms of Malnutrition in Cirrhosis with Portosystemic ShuntingR01GM119174 · NIGMS · CLEVELAND CLINIC LERNER COM-CWRU · PI DASARATHY, SRINIVASAN · 2017 to 2020
$1.2M
Alcohol induces muscle autophagy by a novel AMPK independent PI3K mediated mechanR21AA022742 · NIAAA · CLEVELAND CLINIC LERNER COM-CWRU · PI DASARATHY, SRINIVASAN · 2014 to 2015
$410k
Hyperammonemia reduces skeletal muscle protein synthesis via a beta-catenin-cMyc mediated impaired ribosomal biogenesisR21AR071046 · NIAMS · CLEVELAND CLINIC LERNER COM-CWRU · PI DASARATHY, SRINIVASAN, DAVULURI, GANGARAO · 2017 to 2018
$399k
NIAAA NIH HHS P50 AA024333NIAAA NIH HHS R21 AA022742NIAMS NIH HHS R21 AR071046NIDDK NIH HHS U01 DK061732NIGMS NIH HHS R01 GM119174
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

MyostatinSarcopeniaFibrosisHumansLiver CirrhosisMyostatinammoniahyperammonemic stress responseLiveroutcomeproteostasis

Identifiers

PMID29168629
PMCPMC5700432
OpenAlexW2768199180

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.