Evidence map›Paper›PMID 29168539›Full record

ArticleCardiology journal2019

Severe degenerative aortic stenosis with preserved ejection fraction does not change adipokines serum levels.

Katarzyna Mizia-Stec, Tomasz Bochenek, Błażej Kusz, Magdalena Mizia-Szubryt, Agnieszka Sikora-Puz, Klaudia Gieszczyk-Strózik

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiology journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact, top 74% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Katarzyna Mizia-StecFirst Department of Cardiology, School of Medicine in Katowice, Medical University of Silesia, Katowice Poland.
Tomasz BochenekFirst Department of Cardiology, School of Medicine in Katowice, Medical University of Silesia, Katowice Poland. tbochun1@gmail.com.
Błażej KuszFirst Department of Cardiology, School of Medicine in Katowice, Medical University of Silesia, Katowice Poland.
Magdalena Mizia-SzubrytFirst Department of Cardiology, School of Medicine in Katowice, Medical University of Silesia, Katowice Poland.
Agnieszka Sikora-PuzSecond Department of Cardiology, School of Medicine in Katowice, Medical University of Silesia, Katowice Poland.
Klaudia Gieszczyk-StrózikFirst Department of Cardiology, School of Medicine in Katowice, Medical University of Silesia, Katowice Poland.
Medical University of Silesia · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe role of the adipokines in the pathogenesis of aortic stenosis (AS) is not well established. The aim was to evaluate the relationship between adipokines and clinical characteristics as well as echocardiographic indices and noninvasive markers of vascular remodeling in patients with severe AS with preserved ejection fraction (EF).

methodsSixty-five patients (F/M: 38/27; age: 68.3 ± 9.0 years; body mass index [BMI]: 29.6 ± 4.3 kg/m2) with severe AS with preserved EF: 33 patients with paradoxical low-flow low-gradient AS (PLFLG AS) and 32 patients with normal flow high-gradient AS (NFHG AS) were prospectively enrolled into the study. Twenty-four subjects (F/M: 14/10; age: 65.4 ± 8.7 years; BMI: 29.6 ± 4.3 kg/m2) who matched as to age, sex, BMI and coronary artery disease (CAD) constituted the control group (CG). Clinical data and markers of vascular remodeling were related to the serum adipokines.

resultsThere were no differences in the adipokines concentrations in the AS/CG. Patients with AS and coexisting CAD were characterized by decreased serum adiponectin (9.9 ± 5.5 vs. 12.7 ± 5.8 μg/mL, p = 0.040) and leptin (8.3 ± 7.8 vs. 21.6 ± 17.1 ng/mL, p < 0.001) levels compared to subjects without CAD. There were no differences in the serum adipokines concentrations between patients with PLFLG AS and NFHG AS. Systemic hypertension, diabetes, hyperlipidemia or markers of vascular remodeling did not discriminate adipokines concentrations. Multivariate regression analysis indicated that age (F = 3.02; p = 0.015) and E/E' index (F = 0.87, p = 0.032) were independent predictors of the adiponectin level in the AS group.

conclusionsThe presence of AS with preserved EF did not change the adipokine serum profile. Adipokines levels were modified by coexisting atherosclerosis but not the typical cardiovascular risk factors or the hemodynamic type of AS.

Indexed as

Stroke VolumeVentricular Function, LeftAdipokinesAdiponectinAgedAortic Valve StenosisBiomarkersCase-Control StudiesCoronary Artery DiseaseCytokinesFemaleHumansLeptinMaleMiddle AgedNicotinamide PhosphoribosyltransferaseAdipokinesAdiponectinADIPOQ protein, humanBiomarkersCytokinesLEP protein, humanLeptinNicotinamide Phosphoribosyltransferasenicotinamide phosphoribosyltransferase, humanResistinRETN protein, humanadipokinesaortic stenosisatherosclerosisechocardiographyvascular remodeling

Identifiers

PMID29168539
PMCPMC8084378
OpenAlexW2768979149

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.