ArticleNature chemistry2017
Catalytic diastereo- and enantioselective additions of versatile allyl groups to N-H ketimines.
Article in Nature chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Regiospecific Allenylation of Ketones with Propargyltrichlorosilane.The Journal of organic chemistry · 2026Article
- Sulfonyl-PYBOX/ErClNature communications · 2026Article
- Enantio- and Site-Selective Synthesis of α-Substituted Hydrazines, Pyrazolidines, and Tertiary Alcohols by Copper-Catalyzed Allylic C-N and C-O Bond Formation.Journal of the American Chemical Society · 2026Article
- Enantioselective Synthesis of 2,3-Disubstituted Azetidines via Copper-Catalyzed Boryl Allylation of Azetines.Journal of the American Chemical Society · 2025Article
- Design Approaches That Utilize Ionic Interactions to Control Selectivity in Transition Metal Catalysis.Chemical reviews · 2025Review
- Catalytic Lewis Base Additive Enables Selective Copper-Catalyzed Borylative α-C-H Allylation of Alicyclic Amines.Journal of the American Chemical Society · 2022Article
- Pd-catalyzed [3 + 2] cycloaddition of cyclic ketimines and trimethylenemethanes towardRSC advances · 2021Article
- Recent advances in the chemistry and applications of N-heterocyclic carbenes.Nature reviews. Chemistry · 2021Review
- Enantioselective Copper-Catalyzed Borylative Cyclization for the Synthesis of Quinazolinones.Angewandte Chemie (International ed. in English) · 2021Article
- Asymmetric Catalytic Ketimine Mannich Reactions and Related Transformations.Catalysts (Basel, Switzerland) · 2021Article
- Sulfonate N-Heterocyclic Carbene-Copper Complexes: Uniquely Effective Catalysts for Enantioselective Synthesis of C-C, C-B, C-H, and C-Si Bonds.Angewandte Chemie (International ed. in English) · 2020Review
- Copper-Catalyzed Borylative Couplings with C-N Electrophiles.Angewandte Chemie (International ed. in English) · 2020Review
- Streamlined Catalytic Enantioselective Synthesis of α-Substituted β,γ-Unsaturated Ketones and Either of the Corresponding Tertiary Homoallylic Alcohol Diastereomers.Journal of the American Chemical Society · 2020Article
- Asymmetric synthesis of γ-chiral borylalkanesChemical science · 2020Article
- Beyond Carbon: Enantioselective and Enantiospecific Reactions with Catalytically Generated Boryl- and Silylcopper Intermediates.ACS central science · 2020Review
- Catalytic enantioselective allene-anhydride approach to β,γ-unsaturated enones bearing an α-all-carbon-quarternary center.Chemical science · 2020Article
- Regio- and Enantioselective Synthesis of Trifluoromethyl-Substituted Homoallylic α-Tertiary NHAngewandte Chemie (International ed. in English) · 2020Article
- Enantio- and Diastereoselective Synthesis of Homopropargyl Amines by Copper-Catalyzed Coupling of Imines, 1,3-Enynes, and Diborons.Angewandte Chemie (International ed. in English) · 2020Article
- Diastereo- and Enantioselective Synthesis of Homoallylic Amines Bearing Quaternary Carbon Centers.Journal of the American Chemical Society · 2020Article
- Copper-Hydride-Catalyzed Enantioselective Processes with Allenyl Boronates. Mechanistic Nuances, Scope, and Utility in Target-Oriented Synthesis.Journal of the American Chemical Society · 2019Article
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4 authors.
Funding
Abstract
There are many biologically active organic molecules that contain one or more nitrogen-containing moieties, and broadly applicable and efficient catalytic transformations that deliver them diastereoselectively and/or enantioselectively are much sought after. Various methods for enantioselective synthesis of α-secondary amines are available (for example, from additions to protected/activated aldimines), but those involving ketimines are much less common. There are no reported additions of carbon-based nucleophiles to unprotected/unactivated (or N-H) ketimines. Here, we report a catalytic, diastereo- and enantioselective three-component strategy for merging an N-H ketimine, a monosubstituted allene and B
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