ArticleJournal of clinical and experimental neuropsychology2018
Vulnerabilities in sequencing and task switching in healthy youth offspring of parents with mood disorders.
Article in Journal of clinical and experimental neuropsychology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.
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Who cites it
8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Change in Cognitive Function over the Course of Major Depressive Disorder: A Systematic Review and Meta-analysis.Neuropsychology review · 2025Pooled it
- Cognitive Performance in First-Degree Relatives of Individuals With vs Without Major Depressive Disorder: A Meta-analysis.JAMA psychiatry · 2019Pooled it
- Neural correlates of attentional switching dysfunction in major depressive disorder: Evidence from an event-related potential study with a dual-task paradigm.World journal of psychiatry · 2025Article
- Attenuated cognitive control network connectivity as a mechanism in mother-daughter intergenerational transmission of depression: a preliminary study.Scientific reports · 2025Article
- Putative Risk Biomarkers of Bipolar Disorder in At-risk Youth.Neuroscience bulletin · 2024Review
- Aberrant brain network topology in youth with a familial risk for bipolar disorder: a task-based fMRI connectome study.Journal of child psychology and psychiatry, and allied disciplines · 2024Article
- Current Evidence and Theories in Understanding the Relationship between Cognition and Depression in Childhood and Adolescence: A Narrative Review.Diagnostics (Basel, Switzerland) · 2022Review
- Elevated Amygdala Activity in Young Adults With Familial Risk for Depression: A Potential Marker of Low Resilience.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2020Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
introductionVisuospatial processing and task switching are impaired in individuals with mood disorders. It is unknown whether early deficits are present before mood symptom on set or are related to risk for a specific type of mood disorder. To investigate, we compared visual attention and task switching during sequencing among never-disordered youth with parental family histories of bipolar (BD) and major depressive disorders (MDD) and healthy controls (HC) with no personal or family history of psychopathology.
method8-17-year-old youth of parents with BD (n = 31, "BD-risk"), youth of parents with MDD (n = 49, "MDD-risk"), and demographically similar HC (n = 31, "HC") were examined using the Delis-Kaplan Executive Functioning System Trail Making Test. Seed-based resting-state functional connectivity (RSFC) was collected from a subset of 88 participants (25 BD-risk, 37 MDD-risk, 26 HC) to investigate group differences in RSFC related to visuospatial processing.
resultsBD-risk and MDD-risk offspring had impaired sequencing and task switching, demonstrated by reduced scores on visual scanning, F(2, 108) = 4.12, p = .02, number sequencing, F(2, 88) = 4.75, p = .01, letter sequencing, F(2, 108) = 4.24, p = .02, and number-letter sequencing, F(2, 108) = 4.66, p = .01, compared to scores in HC. RSFC between the posterior cingulate (PCC) and clusters in the subcallosal cortex, amygdala, and hippocampus significantly differed among HC, BD-risk, and MDD-risk groups. PCC-subcallosal/limbic RSFC was positively coupled in the MDD-risk and BD-risk groups and negatively coupled in HCs.
conclusionsYouth at familial risk for mood disorders demonstrate visuospatial deficits early in the processing stream. Improved methods for identifying at-risk children with the earliest possible neurocognitive impairments may inform remediation strategies that could prevent mood disorders.
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