Evidence map›Paper›PMID 29168388›Full record

ArticleBiological research for nursing2018

Primer in Genetics and Genomics, Article 6: Basics of Epigenetic Control.

Kristen L Fessele, Fay Wright

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological research for nursing, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Kristen L Fessele1 Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Fay Wright2 Rory Meyers College of Nursing, New York, NY, USA.

Funding

Research Training: Self and Family ManagementT32NR008346 · NINR · YALE UNIVERSITY · PI GREY, MARGARET · 2003 to 2018
$4.7M
NINR NIH HHS T32 NR008346
6 · The paper itself

Abstract

The epigenome is a collection of chemical compounds that attach to and overlay the DNA sequence to direct gene expression. Epigenetic marks do not alter DNA sequence but instead allow or silence gene activity and the subsequent production of proteins that guide the growth and development of an organism, direct and maintain cell identity, and allow for the production of primordial germ cells (PGCs; ova and spermatozoa). The three main epigenetic marks are (1) histone modification, (2) DNA methylation, and (3) noncoding RNA, and each works in a different way to regulate gene expression. This article reviews these concepts and discusses their role in normal functions such as X-chromosome inactivation, epigenetic reprogramming during embryonic development and PGC production, and the clinical example of the imprinting disorders Angelman and Prader-Willi syndromes.

Indexed as

AnimalsDNA MethylationEmbryonic DevelopmentEpigenesis, GeneticFemaleGene ExpressionGenomicsGerm CellsHumansMaleX Chromosome InactivationchromatinDNA methylationepigenomicshistone codeX-chromosome inactivation

Identifiers

PMID29168388
PMCPMC6949967

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.