Evidence map›Paper›PMID 29168114›Full record

ArticleEndocrine2018

Parathyroid hormone in surgery-induced weight loss: no glucometabolic effects but potential adaptive response to skeletal loading.

Valeria Guglielmi, Alfonso Bellia, Paolo Gentileschi, Mauro Lombardo, Monica D'Adamo, Davide Lauro, Paolo Sbraccia

Abstract read
PubMed Publisher
In one paragraph

Article in Endocrine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 4 pooled it
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 4 syntheses or guidelines pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Review
  7. Article
  8. Article
  9. Environmental Factors That Affect Parathyroid Hormone and Calcitonin Levels.International journal of molecular sciences · 2021
    Review
  10. Article
  11. Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Valeria GuglielmiDepartment of Systems Medicine, Laboratory of Molecular Medicine, University of Rome Tor Vergata, Rome, Italy.ORCID 0000-0002-6912-7814
Alfonso BelliaDepartment of Systems Medicine, Laboratory of Molecular Medicine, University of Rome Tor Vergata, Rome, Italy. bellia@med.uniroma2.it.
Paolo GentileschiDepartment of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.
Mauro LombardoDepartment of Human Sciences and Promotion of the Quality of Life, San Raffaele Roma Open University, Rome, Italy.
Monica D'AdamoDepartment of Systems Medicine, Laboratory of Molecular Medicine, University of Rome Tor Vergata, Rome, Italy.
Davide LauroDepartment of Systems Medicine, Laboratory of Molecular Medicine, University of Rome Tor Vergata, Rome, Italy.
Paolo SbracciaDepartment of Systems Medicine, Laboratory of Molecular Medicine, University of Rome Tor Vergata, Rome, Italy.
University of Rome Tor Vergata · IT

Funding

Ministero della Salute Project n. 45/RF-2013-02357791
6 · The paper itself

Abstract

purposeIncreased parathyroid hormone (PTH) is commonly associated with obesity, and its role in the pathogenesis of obesity-related glucometabolic abnormalities is uncertain. We aimed to explore the relationships of PTH with glucose/insulin homeostasis parameters before and after bariatric surgery-induced weight loss, and whether they depend or not on 25-hydroxyvitamin D (25OHD) status.

methodsWe included 42 subjects (27 women, aged 40 ± 5 years, BMI 48.5 ± 7.3 kg/m

resultsWeight loss was accompanied by significant reduction of PTH levels (77.9 ± 19.1 vs. 60.5 ± 13.4 pg/ml; p = 0.005), without concomitant modification of 25OHD status. Both baseline PTH and its postoperative percent change resulted associated, with baseline fat mass (β = 0.615, p = 0.003) and its concurrent postoperative reduction (r = 0.419; p = 0.006), but neither with glucose homeostasis parameters nor their respective variations after weight loss. Interestingly, leptin reduction after weight loss was independently related to PTH change (β = 0.396, p = 0.015) and IGF-1 levels (β = 0.176, p = 0.059).

conclusionsCirculating PTH decreases with fat mass reduction independent of 25OHD status, but it  is not associated with improvement of insulin resistance and related metabolic parameters. Leptin and PTH may mediate the cross-talk between adipose tissue and parathyroid glands, which possibly contributes to bone adaptation to excess body weight.

Indexed as

Bariatric SurgeryAdultBlood GlucoseBody Mass IndexCalciumFemaleHumansInsulinInsulin ResistanceLeptinMaleMiddle AgedObesity, MorbidParathyroid HormoneVitamin DWeight Loss25-hydroxyvitamin DBlood GlucoseCalciumInsulinLeptinParathyroid HormoneVitamin D25-hydroxyvitamin DBariatric surgeryGlucose homeostasisMineral metabolismObesityParathyroid hormone

Identifiers

PMID29168114
OpenAlexW2770872783

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.