Evidence map›Paper›PMID 29168086›Full record

ArticleBrain imaging and behavior2018

Increased white matter metabolic rates in autism spectrum disorder and schizophrenia.

Serge A Mitelman, Monte S Buchsbaum, Derek S Young, M Mehmet Haznedar, Eric Hollander, Lina Shihabuddin, Erin A Hazlett, Marie-Cecile Bralet

Abstract readComparative Study
In one paragraph

Article in Brain imaging and behavior, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. In vivo translocator protein in females with autism spectrum disorder: a pilot study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 2 countries.

Serge A MitelmanDepartments of Psychiatry and Neuroscience, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA. serge.mitelman@mssm.edu.ORCID http://orcid.org/0000-0003-0591-1316
Monte S BuchsbaumDepartments of Psychiatry and Radiology, San Diego School of Medicine, NeuroPET Center, University of California, 11388 Sorrento Valley Road, Suite #100, San Diego, CA, 92121, USA.
Derek S YoungDepartment of Statistics, University of Kentucky, 725 Rose Street, 323 Multidisciplinary Science Building, Lexington, KY, 40536, USA.
M Mehmet HaznedarDepartments of Psychiatry and Neuroscience, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA.
Eric HollanderAutism and Obsessive-Compulsive Spectrum Program, Anxiety and Depression Program, Department of Psychiatry and Behavioral Science, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, 10467, USA.
Lina ShihabuddinDepartments of Psychiatry and Neuroscience, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA.
Erin A HazlettDepartments of Psychiatry and Neuroscience, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA.
Marie-Cecile BraletCrisalid Unit (FJ5), CHI Clermont de l'Oise, 2 rue des Finets, 60607, Clermont, France.
James J. Peters VA Medical Center · USAlbert Einstein College of Medicine · USElmhurst Hospital Center · USIcahn School of Medicine at Mount Sinai · USInserm · FRUniversity of California San Diego · USUniversity of Kentucky · US

Funding

5-Year DTI/MRI Follow-Up in SchizophreniaR03MH077146 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MITELMAN, SERGE A · 2007 to 2008
$168k
CSR&D Research Career Scientist Award ApplicationIK6CX001738 · VA · JAMES J PETERS VA MEDICAL CENTER · PI HAZLETT, ERIN A. · 2018 to 2022
–
CSRD VA IK6 CX001738NIMH NIH HHS MH077146NIMH NIH HHS R03 MH077146
6 · The paper itself

Abstract

Both autism spectrum disorder (ASD) and schizophrenia are often characterized as disorders of white matter integrity. Multimodal investigations have reported elevated metabolic rates, cerebral perfusion and basal activity in various white matter regions in schizophrenia, but none of these functions has previously been studied in ASD. We used

Indexed as

AdultAutism Spectrum DisorderBrainFemaleFluorodeoxyglucose F18Functional LateralityGray MatterHumansMalePositron-Emission TomographyRadiopharmaceuticalsSchizophreniaWhite MatterFluorodeoxyglucose F18RadiopharmaceuticalsAutism spectrum disorderDorsal and ventral streamsHypermetabolismPositron emission tomographySchizophreniaWhite matter

Identifiers

PMID29168086
PMCPMC13248955
OpenAlexW2769448299

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.