Evidence map›Paper›PMID 29168033›Full record

Trial reportSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2018

A prospective, multicenter pilot study to investigate the feasibility and safety of a 1-year controlled exercise training after adjuvant chemotherapy in colorectal cancer patients.

Gudrun Piringer, Michael Fridrik, Alfred Fridrik, Andreas Leiherer, August Zabernigg, Richard Greil, Wolfgang Eisterer, Jörg Tschmelitsch, Alois Lang, Sophie Frantal and 4 more

Abstract readClinical TrialMulticenter Study
PubMed Publisher
In one paragraph

Trial report in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 1 country.

Gudrun PiringerDepartment of Internal Medicine IV, Klinikum Wels-Grieskirchen, Grieskirchnerstraße 42, A-4600, Wels, Austria. gudrun.piringer@hotmail.com.
Michael FridrikDepartment of Internal Medicine III, Kepler Universitäts Klinikum, Linz, Austria.
Alfred FridrikSports Medicine, Leonding, Austria.
Andreas LeihererVorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Feldkirch, Austria.
August ZaberniggDepartment of Internal Medicine, Hospital Kufstein, Kufstein, Austria.
Richard GreilDepartment of Internal Medicine III, Paracelsus Medical University, Salzburg, Austria.
Wolfgang EistererDepartment of Internal Medicine, Klinikum Klagenfurt am Wörthersee, Klagenfurt, Austria.
Jörg TschmelitschDepartment of Surgery, St. Veit Hospital, Sankt Veit an der Glan, Austria.
Alois LangDepartment of Internal Medicine, Hospital Feldkirch, Feldkirch, Austria.
Sophie FrantalAustrian Breast and Colorectal Cancer Study Group, Vienna, Austria.
Sonja BurgstallerDepartment of Internal Medicine IV, Klinikum Wels-Grieskirchen, Grieskirchnerstraße 42, A-4600, Wels, Austria.
Michael GnantDepartment of Surgery and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
Josef ThalerDepartment of Internal Medicine IV, Klinikum Wels-Grieskirchen, Grieskirchnerstraße 42, A-4600, Wels, Austria.
Austrian Breast and Colorectal Cancer Study Group (ABCSG)
Klinikum Wels-Grieskirchen · ATComprehensive Cancer Center Vienna · ATKepler Universitätsklinikum · ATLandeskrankenhaus Feldkirch · ATParacelsus Medical University · ATVorarlberg Institute for Vascular Investigation and Treatment · ATKlinikum Klagenfurt · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionDespite advances in adjuvant chemotherapy, 20-30% of patients in stages II-III colorectal cancer will eventually relapse. Observational studies showed a reduction in relapse rate, colon cancer-specific mortality, and overall mortality by physical activity. Results from prospective randomized interventional studies to confirm these observational data are lacking. The aims of this prospective single-arm multicenter pilot study are to evaluate feasibility and safety of exercise training after adjuvant chemotherapy in colorectal cancer patients. PATIENTS AND

methodsThe training was performed three times per week for 1 year and was increased gradually in three phases until reaching 18 metabolic equivalent task hours per week.

resultsOverall, 30 patients were included. The planned training intensity could be achieved in all three phases. Patients experienced a performance increase of median 35.5 watt, a weight-loss of a median of 3.0 kg, and a reduction in body fat content of median 1.0% during this exercise training. The analysis showed early study termination due to non-compliance in 10/30 patients (33.3%), disease progression in 4 patients (13.3%), and serious adverse events in 2 patients (6.7%). About half of patients (46.7%) completed the pilot study as planned. Biomarker analysis from 20 patients showed a non-significant reduction in insulin-like growth factor 1 (IGF-1), insulin-like growth factor 2 (IGF-2) and insulin-like growth factor binding protein 3 (IGF-BP3) levels, significant increases in adiponectin and leptin levels, and a non-significant increase in C-peptide levels.

conclusionExercise training is feasible in patients with colorectal cancer after completion of adjuvant chemotherapy. The main problem encountered during the study was compliance. To improve compliance of exercise training, several measures were adapted for the upcoming prospective randomized ABCSG C08 Exercise II study.

Indexed as

ExerciseAdultAgedChemotherapy, AdjuvantColorectal NeoplasmsExercise TherapyFeasibility StudiesFemaleHumansMaleMiddle AgedNeoplasm Recurrence, LocalNeoplasm StagingPatient CompliancePilot ProjectsProspective StudiesAdjuvant therapyBiomarker analysisColorectal cancerExercise trainingPhysical activity

Identifiers

PMID29168033
OpenAlexW2770138832

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.