Evidence map›Paper›PMID 29168015›Full record

ArticleHeart and vessels2018

Ascending aortic blood flow velocity is increased in children with primary snoring/mild sleep-disordered breathing and associated with an increase in CD8

Anna Kontos, Scott Willoughby, Cameron van den Heuvel, Declan Kennedy, James Martin, Greg Hodge, Matthew Worthley, Adelene Kaihui Chin, Adam Nelson, Karen Teo and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Heart and vessels, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Anna KontosRobinson Research Institute, University of Adelaide, 3rd Floor Norwich Building, 55 King William Street, North Adelaide, 5006, Australia. anna.kontos@adelaide.edu.au.ORCID http://orcid.org/0000-0002-3329-1487
Scott WilloughbySouth Australian Health and Medical Research Institute (SAHMRI), Adelaide, Australia.
Cameron van den HeuvelResearch Branch, University of Adelaide, Adelaide, Australia.
Declan KennedyRobinson Research Institute, University of Adelaide, 3rd Floor Norwich Building, 55 King William Street, North Adelaide, 5006, Australia.
James MartinDepartment of Respiratory and Sleep Medicine, Women's and Children's Hospital, Adelaide, Australia.
Greg HodgeLung Research, Thoracic Medicine, Royal Adelaide Hospital, Adelaide, Australia.
Matthew WorthleySouth Australian Health and Medical Research Institute (SAHMRI), Adelaide, Australia.
Adelene Kaihui ChinSchool of Biological Sciences, University of Adelaide, Adelaide, Australia.
Adam NelsonCardiology Department, Royal Adelaide Hospital, Central Adelaide Local Health Network, Adelaide, Australia.
Karen TeoCardiology Department, Royal Adelaide Hospital, Central Adelaide Local Health Network, Adelaide, Australia.
Mathias BaumertSchool of Electrical and Electronic Engineering, University of Adelaide, Adelaide, Australia.
Yvonne PamulaDepartment of Respiratory and Sleep Medicine, Women's and Children's Hospital, Adelaide, Australia.
Kurt LushingtonSchool of Psychology, Social Work and Social Policy, University of South Australia, Adelaide, Australia.

Funding

National Health and Medical Council of Australia project no. 453637
6 · The paper itself

Abstract

Sleep-disordered breathing (SDB) is associated with cardiovascular disease and systemic inflammation in adults but this remains to be explored in children, especially in children with the most common form of SDB, i.e. primary snoring/mild SDB. This pilot study investigated the relationship between the cardiovascular function and inflammation in children with mild SDB. Nineteen participants aged 5-14 years underwent overnight polysomnography, cardiac magnetic resonance imaging (aortic blood flow velocity and left and right ventricular systolic function) and assessment for inflammatory markers (intracellular cytokine analysis of T cells by flow cytometry). Parents also completed the Sleep Disturbances Scale for Children (SDSC). Children with mild SDB exhibited increased ascending aortic peak systolic velocity compared to controls (SDB 119.95 m/s vs. control 101.49 m/s, p < 0.05). No significant group differences were observed for left and right ventricular ejection fraction or mean aortic blood flow velocity from either the ascending aorta or pulmonary artery. Children with mild SDB had increased inflammatory markers as demonstrated by elevated T cell interferon gamma (IFNγ) (SDB 52 ± 4% vs. control 25 ± 3% positive cells, p < 0.005) and tumour necrosis factor alpha (TNFα) (SDB 39 ± 4% vs. control 20 ± 2% positive cells, p < 0.005) expression from CD8

Indexed as

AdolescentAortaBlood Flow VelocityCD8-Positive T-LymphocytesChildChild, PreschoolFemaleHumansInterferon-gammaMalePilot ProjectsPolysomnographySeverity of Illness IndexSleepSleep Apnea, ObstructiveSnoringInterferon-gammaTumor Necrosis Factor-alphaArterial blood flow velocityChildrenInflammationSleep-disordered breathing

Identifiers

PMID29168015

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.