ArticleEuropean journal of pediatrics2018
Clinical features and treatment of pediatric patients with drug-induced anaphylaxis: a study based on pharmacovigilance data.
Article in European journal of pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- RECOVER Guidelines: First Aid. Evidence, Treatment Recommendations, Knowledge Gap Analysis, and Clinical Guidelines for Acute Allergy and Anaphylaxis in Dogs and Cats.Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001) · 2026Article
- Drug-Induced Anaphylaxis in Children: A Comparative Analysis of Inpatient versus Outpatient Settings.International archives of allergy and immunology · 2026Article
- Clinical characteristics of anaphylaxis and risk factors for severe reactions in children: a single-center experience.Frontiers in pediatrics · 2026Article
- Pediatric Anaphylaxis in the Emergency Department: From Mechanisms to Personalized Care.Cureus · 2025Review
- Drug hypersensitivity reactions in children in clinical practice: A WAO Statement.The World Allergy Organization journal · 2025Review
- Drug-Induced Anaphylaxis in Children.Biomedicines · 2024Review
- Drug-Induced Anaphylaxis: National Database Analysis.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Article
- Pediatric Anaphylaxis: A 20-Year Retrospective Analysis.Journal of clinical medicine · 2022Article
- The 2020 update on anaphylaxis in paediatric population.Postepy dermatologii i alergologii · 2022Review
- Age-related differences in characteristics of anaphylaxis in Chinese children from infancy to adolescence.The World Allergy Organization journal · 2021Article
- Drug-induced anaphylactic reactions in children: A retrospective analysis of 159 validated spontaneous reports.Pharmacoepidemiology and drug safety · 2019Article
- Drug-induced anaphylaxis in children.Acta bio-medica : Atenei Parmensis · 2019Review
- Are Kidney-Tonifying and Blood-Activating Medicinal Herbs Better than NSAIDs for Knee Osteoarthritis? A Systematic Review and Meta-Analysis.Evidence-based complementary and alternative medicine : eCAM · 2019Article
- NSAID-induced reactions: classification, prevalence, impact, and management strategies.Journal of asthma and allergy · 2019Review
- Pharmacovigilance in China: development and challenges.International journal of clinical pharmacy · 2018Review
- Traditional Chinese medicine and drug-induced anaphylaxis: data from the Beijing pharmacovigilance database.International journal of clinical pharmacy · 2018Article
- Development and validation of an algorithm to identify drug-induced anaphylaxis in the Beijing Pharmacovigilance Database.International journal of clinical pharmacy · 2018Article
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We assessed the clinical features and treatment of pediatric patients with drug-induced anaphylaxis in clinical settings. Pediatric drug-induced anaphylaxis cases collected by the Beijing Pharmacovigilance Database from 2004 to 2014 were analyzed. A total of 91 cases were identified. Drug-induced anaphylaxis was primarily caused by antibiotics (53%). Children of 0-5 years were more likely to develop cyanosis symptoms than children of 13-17 years (OR = 5.14, 95%CI [1.74, 15.20], P = 0.002). Children of 13-17 years were more likely to develop hypotension than children of 6-12 years (OR = 11.79, 95%CI [2.28, 60.87], P = 0.002), and to manifest both neurological symptoms (OR = 3.56, 95%CI [1.26, 10.08], P = 0.015) and severe anaphylaxis than children of 0-5 years (OR = 15.46, 95%CI [1.85, 129.33], P = 0.002). Supratherapeutic doses of epinephrine were more likely with intravenous (IV) bolus (92%) in contrast to either intramuscular (IM) (36%, OR = 19.25, 95%CI [1.77, 209.55], P = 0.009) or subcutaneous (SC) injections (36%, OR = 19.80, 95% CI [1.94, 201.63], P = 0.005). Only 62 (68%) patients received epinephrine treatment as the first-line therapy.
conclusionThis study demonstrates that antibiotics were the most common cause of pediatric drug-induced anaphylaxis. Children may present with different anaphylactic signs/symptoms based on age groups. Epinephrine is under-utilized and provider education on the proper management of drug-induced anaphylaxis is warranted. What is Known: • The most common causes of anaphylaxis in children are allergies to foods. Drugs are the second most common cause of pediatric anaphylaxis. • IM epinephrine is the recommended initial treatment of anaphylaxis. What is New: • Drug-induced anaphylaxis in pediatric patients has age-related clinical features. • IV bolus epinephrine was overused and associated with supratherapeutic dosing.
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