Evidence map›Paper›PMID 29167564›Full record

ArticleScientific reports2017

Whole Transcriptome Sequencing Analyses Reveal Molecular Markers of Blood Pressure Response to Thiazide Diuretics.

Ana Caroline C Sá, Amy Webb, Yan Gong, Caitrin W McDonough, Somnath Datta, Taimour Y Langaee, Stephen T Turner, Amber L Beitelshees, Arlene B Chapman, Eric Boerwinkle and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 1 country.

Ana Caroline C SáCenter for Pharmacogenomics and Department of Pharmacotherapy and Translational Research, University of Florida, Gainesville, FL, USA.
Amy WebbDepartment of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, OH, USA.
Yan GongCenter for Pharmacogenomics and Department of Pharmacotherapy and Translational Research, University of Florida, Gainesville, FL, USA.
Caitrin W McDonoughCenter for Pharmacogenomics and Department of Pharmacotherapy and Translational Research, University of Florida, Gainesville, FL, USA.
Somnath DattaDepartment of Biostatistics, University of Florida, Gainesville, FL, USA.
Taimour Y LangaeeCenter for Pharmacogenomics and Department of Pharmacotherapy and Translational Research, University of Florida, Gainesville, FL, USA.ORCID 0000-0001-5040-6365
Stephen T TurnerDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.
Amber L BeitelsheesDivision of Endocrinology, Diabetes and Nutrition, University of Maryland, Baltimore, MD, USA.
Arlene B ChapmanDepartment of Medicine, University of Chicago, Chicago, IL, USA.
Eric BoerwinkleDivision of Epidemiology, University of Texas at Houston, Houston, TX, USA.
John G GumsDepartment of Community Health and Family Medicine, University of Florida College of Medicine, Gainesville, FL, USA.
Steven E SchererHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.
Rhonda M Cooper-DeHoffCenter for Pharmacogenomics and Department of Pharmacotherapy and Translational Research, University of Florida, Gainesville, FL, USA.
Wolfgang SadeeCenter for Pharmacogenomics, Department of Cancer Biology and Genetic, College of Medicine, Ohio State University, Columbus, OH, USA.
Julie A JohnsonCenter for Pharmacogenomics and Department of Pharmacotherapy and Translational Research, University of Florida, Gainesville, FL, USA. johnson@cop.ufl.edu.
University of Florida · USThe Ohio State University · USAmerican Association of Colleges of Pharmacy · USBaylor College of Medicine · USMayo Clinic · USThe University of Texas Health Science Center at Houston · USUniversity of Chicago · USUniversity of Maryland, Baltimore · US

Funding

Mayo Clinic Center for Translational Science ActivitiesUL1TR000135 · NCATS · MAYO CLINIC ROCHESTER · PI KHOSLA, SUNDEEP · 2012 to 2015
$41.2M
Using social networks to map and evaluate team science across CTSA hubsUL1TR001427 · NCATS · UNIVERSITY OF FLORIDA · PI MITCHELL, DUANE A. · 2015 to 2024
$37.2M
Atlanta Clinical and Translational Science Institute (ACTSI) RenewalUL1TR000454 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$25.8M
Pharmacogenomic Evaluation of Antihypertensive ResponsesU01GM074492 · NIGMS · UNIVERSITY OF FLORIDA · PI JOHNSON, JULIE A. · 2005 to 2014
$20.7M
Pharmacogenomics of Membrane TransportersU19GM061390 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KWOK, PUI-YAN · 2010 to 2014
$16.3M
Pharmacogenetics of Phase II Drug Metabolizing EnzymesU19GM061388 · NIGMS · MAYO CLINIC ROCHESTER · PI WANG, LIEWEI, WEINSHILBOUM, RICHARD M. · 2010 to 2014
$15.8M
UF Clinical and Translational Science AwardUL1TR000064 · NCATS · UNIVERSITY OF FLORIDA · PI NELSON, DAVID R · 2012 to 2014
$12.2M
NCATS NIH HHS UL1 TR000064NCATS NIH HHS UL1 TR000135NCATS NIH HHS UL1 TR000454NCATS NIH HHS UL1 TR001427NIGMS NIH HHS U01 GM074492NIGMS NIH HHS U19 GM061388NIGMS NIH HHS U19 GM061390
6 · The paper itself

Abstract

Thiazide diuretics (TD) are commonly prescribed anti-hypertensives worldwide. However, <40% of patients treated with thiazide monotherapy achieve BP control. This study uses whole transcriptome sequencing to identify novel molecular markers associated with BP response to TD. We assessed global RNA expression levels in whole blood samples from 150 participants, representing patients in the upper and lower quartile of BP response to TD from the Pharmacogenomic Evaluation of Antihypertensive Responses (PEAR) (50 whites) and from PEAR-2 (50 whites and 50 blacks). In each study cohort, we performed poly-A RNA-sequencing in baseline samples from 25 responders and 25 non-responders to hydrochlorothiazide (HCTZ) or chlorthalidone. At FDR adjusted p-value < 0.05, 29 genes were differentially expressed in relation to HCTZ or chlorthalidone BP response in whites. For each differentially expressed gene, replication was attempted in the alternate white group and PEAR-2 blacks. CEBPD (meta-analysis p = 1.8 × 10

Indexed as

Gene Expression ProfilingAllelesBiomarkersBlood PressureCCAAT-Enhancer-Binding Protein-deltaChlorthalidoneDiureticsFemaleGene Expression RegulationHumansHydrochlorothiazideLogistic ModelsMaleMiddle AgedPotassiumReproducibility of ResultsBiomarkersCCAAT-Enhancer-Binding Protein-deltaCEBPD protein, humanChlorthalidoneDiureticsHydrochlorothiazidePotassiumRNA, MessengerTranscription FactorsTSC22D3 protein, humanUric Acid

Identifiers

PMID29167564
PMCPMC5700078
OpenAlexW2770078338

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.