ArticleScience translational medicine2017
Prion seeding activity and infectivity in skin samples from patients with sporadic Creutzfeldt-Jakob disease.
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In one paragraph
Article in Science translational medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed, 1 pooled it
5.9field-weighted citation impact, top 3% of its field
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Who cites it
86 citing papers in PubMed, 1 synthesis or guideline pooled it, 144 citations in OpenAlex.
- Interventions to reduce the risk of surgically transmitted Creutzfeldt-Jakob disease: a cost-effective modelling review.Health technology assessment (Winchester, England) · 2020Pooled it
- From a prion seed to a tree of discoveries: Byron Caughey's RT-QuIC legacy in protein misfolding research.Acta neuropathologica · 2026Review
- Co- and Multi-Pathologies in Parkinson's Disease: An International Parkinson and Movement Disorder Society Scientific Issues Committee Review.Movement disorders : official journal of the Movement Disorder Society · 2026Review
- Alpha-synuclein seeding activity in postmortem tissues from patients with diffuse and isolated Lewy bodies.Acta neuropathologica communications · 2026Article
- Prions and protein aggregates as pathogens, self-propagating structures, biomarkers, and therapeutic targets.Microbiology and molecular biology reviews : MMBR · 2025Review
- Large-scale seroepidemiology uncovers nephro-urological pathologies in people with tau autoimmunity.PLoS biology · 2025Article
- Revision and update of the position paper on the management of notifications of donors with Creutzfeldt-Jakob disease in Italy.Blood transfusion = Trasfusione del sangue · 2025Article
- Tracking Prions by RT-QuIC: An Update.Sub-cellular biochemistry · 2025Review
- Advancing Prion Diagnostics: RT-QuIC Applications in Peripheral Tissues.Sub-cellular biochemistry · 2025Review
- Biological Fluid Biomarkers in Human Prion Diseases with a Note on Biosafety.Sub-cellular biochemistry · 2025Review
- Diagnosis of Prion Diseases.Sub-cellular biochemistry · 2025Review
- Prion Disease Diagnostic Biomarker Utility in Pre-symptomatic Disease.Sub-cellular biochemistry · 2025Review
- Multisite Skin Biopsies vs Cerebrospinal Fluid for Prion Seeding Activity in the Diagnosis of Prion Diseases.JAMA neurology · 2024Article
- Review
- Seeding activity of skin misfolded tau as a biomarker for tauopathies.Molecular neurodegeneration · 2024Article
- Review
- Seeding activity of human superoxide dismutase 1 aggregates in familial and sporadic amyotrophic lateral sclerosis postmortem neural tissues by real-time quaking-induced conversion.Acta neuropathologica · 2024Article
- Detection of prions in matching post-mortem skin and cerebrospinal fluid samples using second-generation real-time quaking-induced conversion assay.Scientific reports · 2024Article
- Creutzfeldt-Jakob disease and other prion diseases.Nature reviews. Disease primers · 2024Review
- Large-scale validation of skin prion seeding activity as a biomarker for diagnosis of prion diseases.Acta neuropathologica · 2024Article
26 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
23 authors at 9 institutions in 3 countries.
Christina D OrrúLaboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.ORCID http://orcid.org/0000-0001-7253-2944
Jue YuanDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.ORCID http://orcid.org/0000-0002-6600-0084
Brian S ApplebyDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.ORCID http://orcid.org/0000-0003-2275-3292
Baiya LiDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.ORCID http://orcid.org/0000-0002-2988-6728
Yu LiDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.ORCID http://orcid.org/0000-0002-9728-0170
Dane WinnerUniversity Hospital Translational Laboratory, University Hospitals Cleveland Medical Center, Cleveland, OH 44106, USA.ORCID http://orcid.org/0000-0002-5256-1665
Zerui WangDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.ORCID http://orcid.org/0000-0003-1784-1079
Yi-An ZhanDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.ORCID http://orcid.org/0000-0002-6618-2308
Mark RodgersDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Jason RarickDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Robert E WyzaHuman Tissue Procurement Facility, Comprehensive Cancer Center Tissue Resources Core, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.ORCID http://orcid.org/0000-0002-9136-2730
Tripti JoshiHuman Tissue Procurement Facility, Comprehensive Cancer Center Tissue Resources Core, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.ORCID http://orcid.org/0000-0001-7840-7597
Gong-Xian WangFirst Affiliated Hospital, Nanchang University, Nanchang, Jiangxi Province, People's Republic of China.
Mark L CohenDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Shulin ZhangDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Bradley R GrovemanLaboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.ORCID http://orcid.org/0000-0002-5059-7672
Robert B PetersenFoundation Sciences, Central Michigan University College of Medicine, Mount Pleasant, MI 48859, USA.ORCID http://orcid.org/0000-0002-3154-0072
James W IronsideNational CJD Research and Surveillance Unit, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0001-5869-2108
Miguel E Quiñones-MateuDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.ORCID http://orcid.org/0000-0001-9170-5601
Jiri G SafarDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.ORCID http://orcid.org/0000-0003-2209-0070
Qingzhong KongDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA. wxz6@case.edu bcaughey@nih.gov qingzhong.kong@case.edu.ORCID http://orcid.org/0000-0003-0298-5264
Byron CaugheyLaboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA. wxz6@case.edu bcaughey@nih.gov qingzhong.kong@case.edu.ORCID http://orcid.org/0000-0002-3928-6101
Wen-Quan ZouDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA. wxz6@case.edu bcaughey@nih.gov qingzhong.kong@case.edu.ORCID http://orcid.org/0000-0001-8062-0370
University School · USNanchang University · CNUniversity Hospitals of Cleveland · USNational Institutes of Health · USCase Western Reserve University · USCentral Michigan University · USFirst Affiliated Hospital of Xi'an Jiaotong University · CNJilin University · CNUniversity of Edinburgh · GB
Funding
Detection of PrionsZIAAI001086 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI CAUGHEY, BYRON · 2009 to 2025
$18.1MPathogenicity of prion protein aggregates from uninfected cells and brainsR01NS062787 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI ZOU, WEN-QUAN · 2009 to 2013
$1.4MCervid to human prion transmissionR01NS088604 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI KONG, QINGZHONG · 2015 to 2018
$1.4MGenerating iPSC-derived Neurons to Explore Formation & Inhibition of Human PrionsR21NS087588 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI QI, XIN, TESAR, PAUL JOSEPH · 2014 to 2015
$436kAccessing transmissibility and diagnostic marker of skin prions.R21NS096626 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI KONG, QINGZHONG, SAFAR, JIRI G. · 2016 to 2017
$436kMedical Research Council G0600953Medical Research Council G0900580NINDS NIH HHS R01 NS062787NINDS NIH HHS R01 NS088604NINDS NIH HHS R21 NS087588NINDS NIH HHS R21 NS096626
Abstract
Sporadic Creutzfeldt-Jakob disease (sCJD), the most common human prion disease, is transmissible through iatrogenic routes due to abundant infectious prions [misfolded forms of the prion protein (PrP
Indexed as
AgedAnimalsBiological AssayBrainCreutzfeldt-Jakob SyndromeDisease Models, AnimalFemaleHumansIn Vitro TechniquesMaleMice, TransgenicMiddle AgedPrion DiseasesPrionsSkinPrions
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.