Evidence map›Paper›PMID 29167345›Full record

ArticleJournal of virology2018

Merkel Cell Polyomavirus Infection of Animal Dermal Fibroblasts.

Wei Liu, Nathan A Krump, Margo MacDonald, Jianxin You

Erratum issuedOpen access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
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  15. Article
  16. Merkel Cell Polyomavirus Infection and Detection.Journal of visualized experiments : JoVE · 2019
    Article
  17. Human polyomaviruses and cancer: an overview.Clinics (Sao Paulo, Brazil) · 2018
    Review
  18. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Wei LiuDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Nathan A KrumpDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Margo MacDonaldDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Jianxin YouDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA jianyou@mail.med.upenn.edu.
University of Pennsylvania · US

Funding

UNIVERSITY OF PENNSYLVANIA CAN CTR SUPPORT GRANTP30CA016520 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Robert H. Vonderheide · 1985 to 2026
$222.3M
Virus & Reservoirs CoreP30AI045008 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Ronald G Collman · 1999 to 2026
$78.6M
Study Design and Data AnalysisP30AR069589 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI Elizabeth Anne Grice · 2016 to 2026
$8.6M
Merkel cell polyomavirus infection, host response, and viral oncogenic mechanismR01CA187718 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Jianxin You · 2015 to 2026
$3.7M
PROTEIN DEGRADATION IN AGING HUMAN FIBROBLASTSR01AG006116 · NIA · TUFTS UNIVERSITY BOSTON · PI DICE, JAMES F · 1985 to 2005
$1.8M
Chromatin structure maintenance and cancerR01CA148768 · NCI · UNIVERSITY OF PENNSYLVANIA · PI YOU, JIANXIN · 2010 to 2014
$1.6M
PROTEIN DEGRADATION IN AGING HUMAN FIBROBLASTSR37AG006116 · NIA · TUFTS UNIVERSITY BOSTON · PI DICE, JAMES F · 1990 to 1999
–
NCI NIH HHS P30 CA016520NCI NIH HHS R01 CA148768NCI NIH HHS R01 CA187718NIAID NIH HHS P30 AI045008NIAMS NIH HHS P30 AR069589NIA NIH HHS R01 AG006116NIA NIH HHS R37 AG006116
6 · The paper itself

Abstract

Merkel cell polyomavirus (MCPyV) is the first polyomavirus to be associated with human cancer. Mechanistic studies attempting to fully elucidate MCPyV's oncogenic mechanisms have been hampered by the lack of animal models for MCPyV infection. In this study, we examined the ability of MCPyV-GFP pseudovirus (containing a green fluorescent protein [GFP] reporter construct), MCPyV recombinant virions, and several MCPyV chimeric viruses to infect dermal fibroblasts isolated from various model animals, including mouse (

Indexed as

Virus ReplicationAnimalsAntigens, Viral, TumorCarcinoma, Merkel CellDisease Models, AnimalDNA ReplicationFemaleFibroblastsGene ExpressionHEK293 CellsHumansMaleMerkel cell polyomavirusMicePan troglodytesPolyomavirus InfectionsAntigens, Viral, Tumoranimal dermal fibroblastsMerkel cell polyomavirusviral life cycle

Identifiers

PMID29167345
PMCPMC5790942
OpenAlexW2770632366

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.