Evidence map›Paper›PMID 29167337›Full record

ArticleJournal of virology2018

Differential Immunodominance Hierarchy of CD8

Emily Adland, Matilda Hill, Nora Lavandier, Anna Csala, Anne Edwards, Fabian Chen, Marek Radkowski, Justyna D Kowalska, Dimitrios Paraskevis, Angelos Hatzakis and 30 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. CD8Frontiers in microbiology · 2021
    Article
  10. Canonical Wnts Mediate CD8Journal of immunology (Baltimore, Md. : 1950) · 2020
    Article
  11. Article
  12. Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

40 authors at 20 institutions in 9 countries.

Emily AdlandDepartment of Paediatrics, University of Oxford, United Kingdom.
Matilda HillDepartment of Paediatrics, University of Oxford, United Kingdom.
Nora LavandierDepartment of Paediatrics, University of Oxford, United Kingdom.
Anna CsalaDepartment of Paediatrics, University of Oxford, United Kingdom.
Anne EdwardsDepartment of GU Medicine, The Churchill Hospital, Oxford University NHS Foundation Trust, Oxford, United Kingdom.
Fabian ChenDepartment of Sexual Health, Royal Berkshire Hospital, Reading, United Kingdom.
Marek RadkowskiDepartment of Immunopathology of Infectious and Parasitic Diseases, Hospital for Infectious Diseases, Medical University of Warsaw, Warsaw, Poland.
Justyna D KowalskaDepartment of Immunopathology of Infectious and Parasitic Diseases, Hospital for Infectious Diseases, Medical University of Warsaw, Warsaw, Poland.
Dimitrios ParaskevisMedical School, National and Kapodistrian University of Athens, Athens, Greece.
Angelos HatzakisMedical School, National and Kapodistrian University of Athens, Athens, Greece.
Humberto Valenzuela-PonceCentre for Research in Infectious Diseases, National Institute of Respiratory Diseases, Mexico City, Mexico.
Katja PfafferottNuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Ian WilliamsCentre for Sexual Health and HIV Research, Mortimer Market Centre, London, United Kingdom.
Pierre PellegrinoCentre for Sexual Health and HIV Research, Mortimer Market Centre, London, United Kingdom.
Persephone BorrowNuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Masahiko MoriDepartment of Paediatrics, University of Oxford, United Kingdom.
Jürgen RockstrohDepartment of Medicine I, University Hospital Bonn, Bonn, Germany.
Julia G PradoAIDS Research Institute IrsiCaixa, Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol (IGTP), Universitat Autònoma de Barcelona, Badalona, Spain.
Beatriz MotheAIDS Research Institute IrsiCaixa, Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol (IGTP), Universitat Autònoma de Barcelona, Badalona, Spain.
Judith DalmauAIDS Research Institute IrsiCaixa, Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol (IGTP), Universitat Autònoma de Barcelona, Badalona, Spain.
Javier Martinez-PicadoAIDS Research Institute IrsiCaixa, Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol (IGTP), Universitat Autònoma de Barcelona, Badalona, Spain.
Gareth Tudor-WilliamsDepartment of Paediatrics, Imperial College, London, United Kingdom.
John FraterNuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Anette StryhnDepartment of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.
Soren BuusDepartment of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.
Gustavo Reyes TeranCentre for Research in Infectious Diseases, National Institute of Respiratory Diseases, Mexico City, Mexico.
Simon MallalDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Mina JohnInstitute of Immunology and Infectious Diseases, Murdoch University, Perth, Australia.
Susan BuchbinderSan Francisco Department of Public Health, HIV Research Section, San Francisco, California, USA.
Gregory KirkDepartment of Epidemiology, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, Maryland, USA.
Jeffrey MartinDepartment of Epidemiology and Biostatistics, University of California, San Francisco, California, USA.
Nelson MichaelU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Jacques FellaySchool of Life Sciences, EPFL, Lausanne, Switzerland.
Steve DeeksSan Francisco Department of Public Health, HIV Research Section, San Francisco, California, USA.
Bruce WalkerRagon Institute of MGH, MIT and Harvard, Boston, Massachusetts, USA.
Santiago Avila-RiosCentre for Research in Infectious Diseases, National Institute of Respiratory Diseases, Mexico City, Mexico.
David ColeCardiff University School of Medicine, Heath Park, Cardiff, United Kingdom.
Christian BranderAIDS Research Institute IrsiCaixa, Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol (IGTP), Universitat Autònoma de Barcelona, Badalona, Spain.
Mary CarringtonRagon Institute of MGH, MIT and Harvard, Boston, Massachusetts, USA.
Philip GoulderDepartment of Paediatrics, University of Oxford, United Kingdom philip.goulder@paediatrics.ox.ac.uk.
University of Oxford · GBIrsiCaixa · ESInstitut d'Investigació en Ciències de la Salut Germans Trias i Pujol · ESMedical University of Warsaw · PLMortimer Market Centre · GBNational and Kapodistrian University of Athens · GRSan Francisco Department of Public Health · USUniversity of Copenhagen · DKCardiff University · GBÉcole Polytechnique Fédérale de Lausanne · CHImperial College London · GBJohns Hopkins University · USLeidos (United States) · USMurdoch University · AURagon Institute of MGH, MIT and Harvard · USRoyal Berkshire Hospital · GBUniversity Hospital Bonn · DEUniversity of California, San Francisco · USVanderbilt University Medical Center · USWalter Reed Army Institute of Research · US

Funding

Unsolicited R24 for the CFAR-Network of Integrated Clinical Sciences, CNICSR24AI067039 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Michael S. Saag · 2006 to 2026
$99.4M
Virology CoreP30AI027763 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STEVEN Grant DEEKS · 1988 to 2026
$93.6M
NATURAL HISTORY OF AIDS IN HOMOSEXUAL MENU01AI035040 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DETELS, ROGER, MARTINEZ-MAZA, OTONIEL · 1993 to 2018
$75.2M
University of Pittsburgh Multicenter AIDS Cohort Study (MACS)U01AI035041 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MARTINSON, JEREMY JAMES, RINALDO, CHARLES R · 1993 to 2018
$71.4M
MULTICENTER AIDS COHORT STUDYU01AI035039 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WOLINSKY, STEVEN M · 1993 to 2018
$66.4M
Multicenter Aids Cohort Study- Part B (Baltimore Site)U01AI035042 · NIAID · JOHNS HOPKINS UNIVERSITY · PI BROWN, TODD T, MARGOLICK, JOSEPH B. · 1993 to 2018
$61.5M
Viral reservoirs and sanctuaries in HAART - treated patients: role and mechanismsU19AI096109 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SCHACKER, TIMOTHY W · 2011 to 2015
$29.5M
Center for the Analysis & Management of the Multicenter AIDS Cohort StudyUM1AI035043 · NIAID · JOHNS HOPKINS UNIVERSITY · PI D'SOUZA, GYPSYAMBER, JACOBSON, LISA P · 2012 to 2018
$20.7M
Effects of genetic polymorphism in MHC, KIR, and related loci on human diseaseZIABC010791 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI CARRINGTON, MARY N. · 2009 to 2025
$18.2M
Molecular genetics and population studies of the KIR and HLA gene complexesZIABC010792 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI CARRINGTON, MARY N. · 2009 to 2025
$7.8M
Optimizing CD8+ T-cell responses against C clade HIV infection in subSaharan AfriR01AI046995 · NIAID · UNIVERSITY OF OXFORD · PI GOULDER, PHILIP J · 2000 to 2014
$6.8M
CCR NIH HHS HHSN261200800001CMedical Research Council MR/K012037Medical Research Council MR/K012037/1Medical Research Council MR/L006588/1NCI NIH HHS HHSN261200800001ENIAID NIH HHS P30 AI027763NIAID NIH HHS R01 AI046995NIAID NIH HHS R24 AI067039NIAID NIH HHS U01 AI035039NIAID NIH HHS U01 AI035040NIAID NIH HHS U01 AI035041NIAID NIH HHS U01 AI035042NIAID NIH HHS U19 AI096109NIAID NIH HHS UM1 AI035043Wellcome TrustWellcome Trust WT104748MA
6 · The paper itself

Abstract

The well-characterized association between HLA-B*27:05 and protection against HIV disease progression has been linked to immunodominant HLA-B*27:05-restricted CD8

Indexed as

CD8-Positive T-Lymphocytesgag Gene Products, Human Immunodeficiency VirusGenes, MHC Class IHIV-1HIV InfectionsHLA-B27 AntigenHumansImmunodominant Epitopesnef Gene Products, Human Immunodeficiency VirusViral Loadgag Gene Products, Human Immunodeficiency VirusHLA-B*27:05 antigenHLA-B27 AntigenImmunodominant Epitopesnef Gene Products, Human Immunodeficiency VirusCD8+ T cellHIV GagHIV NefHLAHLA-B*27human immunodeficiency virus

Identifiers

PMID29167337
PMCPMC5790925
OpenAlexW2769058266

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.