Evidence map›Paper›PMID 29167295›Full record

ArticleThe European respiratory journal2017

Sex-specific impact of asthma during pregnancy on infant gut microbiota.

Petya T Koleva, Hein M Tun, Theodore Konya, David S Guttman, Allan B Becker, Piush J Mandhane, Stuart E Turvey, Padmaja Subbarao, Malcolm R Sears, James A Scott and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The European respiratory journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. Review
  5. Sex, hormones, and lung health.Physiological reviews · 2026
    Review
  6. Article
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  8. Article
  9. Maternal asthma in relation to infant size and body composition.The journal of allergy and clinical immunology. Global · 2023
    Article
  10. Review
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  12. Article
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  14. Article
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Petya T KolevaDept of Pediatrics, University of Alberta, Edmonton, AB, Canada.
Hein M TunDept of Pediatrics, University of Alberta, Edmonton, AB, Canada.
Theodore KonyaDalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
David S GuttmanCell and Systems Biology, University of Toronto, Toronto, ON, Canada.
Allan B BeckerDept of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada.
Piush J MandhaneDept of Pediatrics, University of Alberta, Edmonton, AB, Canada.
Stuart E TurveyDept of Pediatrics, University of British Columbia, Vancouver, BC, Canada.
Padmaja SubbaraoDept of Pediatric Respiratory Medicine, University of Toronto, Toronto, ON, Canada.
Malcolm R SearsDept of Medicine, McMaster University, Hamilton, ON, Canada.
James A ScottDalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
Anita L KozyrskyjDept of Pediatrics, University of Alberta, Edmonton, AB, Canada kozyrsky@ualberta.ca.
CHILD Study Investigators
University of Alberta · CAUniversity of Toronto · CAMcMaster University · CAPublic Health Ontario · CAUniversity of British Columbia · CAUniversity of Manitoba · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Asthma during pregnancy is associated with retardation of fetal growth in a sex-specific manner. Lactobacilli microbes influence infant growth. This study aimed to determine whether lactobacilli and other microbes are reduced in the gut of infants born to an asthmatic mother, and whether this differs by the sex of the infant.Mother-infant pairs (N=1021) from the Canadian Healthy Infant Longitudinal Development full-term cohort were studied. The abundance of infant faecal microbiota at 3-4 months, profiled by gene sequencing, was compared between both women with and without asthma treatment during pregnancy. Infant sex, maternal ethnicity, pre-pregnancy overweight and atopy status, birth mode, breastfeeding status and intrapartum antibiotic treatment were tested as covariates.Independent of birth mode and other covariates, male, Caucasian infants born to women with prenatal asthma harboured fewer lactobacilli in the gut at 3-4 months of age. If asthmatic mothers had pre-pregnancy overweight, the abundance of

Indexed as

Gastrointestinal MicrobiomeSex FactorsAdultAnti-Bacterial AgentsAsthmaCanadaCohort StudiesFecesFemaleHumansInfantInfant, NewbornLactobacillusLogistic ModelsMaleOverweightAnti-Bacterial Agents

Identifiers

PMID29167295
PMCPMC5898939
OpenAlexW2770689536

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.