Evidence map›Paper›PMID 29167290›Full record

ArticleJournal of clinical microbiology2018

Evaluation of Whole-Genome Sequencing for Mycobacterial Species Identification and Drug Susceptibility Testing in a Clinical Setting: a Large-Scale Prospective Assessment of Performance against Line Probe Assays and Phenotyping.

T Phuong Quan, Zharain Bawa, Dona Foster, Tim Walker, Carlos Del Ojo Elias, Priti Rathod, MMM Informatics Group, Zamin Iqbal, Phelim Bradley, Janet Mowbray and 5 more

Open access · hybridAbstract readComparative StudyEvaluation Study
In one paragraph

Article in Journal of clinical microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 1 pooled it
8.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 1 synthesis or guideline pooled it, 99 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Diagnostic Accuracy of AdvanSureDiagnostics (Basel, Switzerland) · 2025
    Article
  6. Article
  7. Article
  8. Evidence ofFrontiers in veterinary science · 2025
    Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. The European respiratory journal · 2023
    Article
  18. Article
  19. Article
  20. A very sneaky bug: perspectives of front-line clinicians on whole-genome sequencing for drug-resistant TB.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

T Phuong QuanThe National Institute for Health Research (NIHR) Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, University of Oxford, Oxford, United Kingdom phuong.quan@ndm.ox.ac.uk.ORCID 0000-0001-8566-1817
Zharain BawaPublic Health England National Mycobacterial Reference Service, Birmingham, United Kingdom.
Dona FosterThe National Institute for Health Research (NIHR) Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, University of Oxford, Oxford, United Kingdom.
Tim WalkerNuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Carlos Del Ojo EliasNuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Priti RathodPublic Health England National Mycobacterial Reference Service, Birmingham, United Kingdom.
MMM Informatics Group
Zamin IqbalWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.ORCID 0000-0001-8466-7547
Phelim BradleyWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
Janet MowbrayPublic Health England National Mycobacterial Reference Service, Birmingham, United Kingdom.
A Sarah WalkerThe National Institute for Health Research (NIHR) Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, University of Oxford, Oxford, United Kingdom.
Derrick W CrookThe National Institute for Health Research (NIHR) Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, University of Oxford, Oxford, United Kingdom.
David H WyllieNuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Timothy E A PetoThe National Institute for Health Research (NIHR) Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, University of Oxford, Oxford, United Kingdom.
E Grace SmithPublic Health England National Mycobacterial Reference Service, Birmingham, United Kingdom.
Public Health England · GBCentre for Human Genetics · GBNational Institute for Health Research · GBUniversity of Oxford · GB

Funding

Department of HealthMedical Research Council MR/J011398/1Medical Research Council MR/K023985/1Wellcome TrustWellcome Trust 102541/Z/13/ZWellcome Trust T5-358Wellcome Trust WT098615
6 · The paper itself

Abstract

Use of whole-genome sequencing (WGS) for routine mycobacterial species identification and drug susceptibility testing (DST) is becoming a reality. We compared the performances of WGS and standard laboratory workflows prospectively, by parallel processing at a major mycobacterial reference service over the course of 1 year, for species identification, first-line

Indexed as

Antitubercular AgentsDrug Resistance, BacterialGenome, BacterialHumansIsoniazidMolecular TypingMycobacterium tuberculosisProspective StudiesRifampinSensitivity and SpecificityTime FactorsTuberculosisAntitubercular AgentsIsoniazidRifampinline probe assaymycobacteriaphenotypeWGSwhole-genome sequencing

Identifiers

PMID29167290
PMCPMC5786738
OpenAlexW2770557999

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.