ArticleClinical cancer research : an official journal of the American Association for Cancer Research2018
PTEN Loss Promotes Intratumoral Androgen Synthesis and Tumor Microenvironment Remodeling via Aberrant Activation of RUNX2 in Castration-Resistant Prostate Cancer.
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Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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41citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
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Who cites it
41 citing papers in PubMed, 72 citations in OpenAlex.
- Endogenous glucocorticoids and glucocorticoid receptor signaling: Dual regulators of PD-1/PD-L1 immunotherapy efficacy in the tumor microenvironment.Chinese medical journal · 2026Review
- Steroidogenesis is associated with bladder cancer progression via reprogramming the metabolic landscape of the tumor immune microenvironment.Discover oncology · 2026Article
- Transcriptional and epigenetic reprogramming, lineage plasticity and therapy resistance in prostate cancer.Journal of the National Cancer Center · 2026Review
- STARD4 suppresses tumorigenesis and attenuates enzalutamide resistance via lipid metabolic reprogramming and AR stabilization in prostate cancer.Journal of experimental & clinical cancer research : CR · 2025Article
- KBTBD11 loss promotes AKT hyperactivation and therapeutic vulnerability in prostate cancer.Oncogene · 2025Article
- Osteocalcin Ameliorates CUMS-Induced Depressive-Like Behaviors by Reducing Mitochondrial Damage in Hippocampal Neurons.CNS neuroscience & therapeutics · 2025Article
- PTEN restoration and CXCR2 depletion synergistically enhance the effect of enzalutamide and inhibit bone metastatic CRPC.Theranostics · 2025Article
- Androgen deprivation therapy exacerbates Alzheimer's-associated cognitive decline via increased brain immune cell infiltration.Science advances · 2024Article
- Synthetic lethal approaches to target cancers with loss of PTEN function.Genes & diseases · 2023Article
- PET imaging of new target CDK19 in prostate cancer.European journal of nuclear medicine and molecular imaging · 2023Article
- Runt-related transcription factors in human carcinogenesis: a friend or foe?Journal of cancer research and clinical oncology · 2023Review
- A comprehensive analysis of FBN2 in bladder cancer: A risk factor and the tumour microenvironment influencer.IET systems biology · 2023Article
- Review
- Dual contribution of the mTOR pathway and of the metabolism of amino acids in prostate cancer.Cellular oncology (Dordrecht, Netherlands) · 2022Review
- Characterization of a castrate-resistant prostate cancer xenograft derived from a patient of West African ancestry.Prostate cancer and prostatic diseases · 2022Article
- Prognostic value and immune characteristics of RUNX gene family in human cancers: a pan-cancer analysis.Aging · 2022Article
- Evolving cancer-niche interactions and therapeutic targets during bone metastasis.Nature reviews. Cancer · 2022Review
- Endocrine Disruptors and Prostate Cancer.International journal of molecular sciences · 2022Review
- Dynamic Changes in Myofibroblasts Affect the Carcinogenesis and Prognosis of Bladder Cancer Associated With Tumor Microenvironment Remodeling.Frontiers in cell and developmental biology · 2022Article
- Macrophage-Derived Cholesterol Contributes to Therapeutic Resistance in Prostate Cancer.Cancer research · 2021Article
Corrections and comments
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Authors and funding
16 authors at 1 institution in 1 country.
Yinhui YangDepartment of Urology, The Fourth Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Yang BaiDepartment of Urology, The Fourth Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Yundong HeDepartment of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota.
Yu ZhaoDepartment of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota.
Jiaxiang ChenDepartment of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota.
Linlin MaDepartment of Urology, University of Kansas Medical Center, Kansas City, Kansas.
Yunqian PanDepartment of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota.
Michael HintenDepartment of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota.
Jun ZhangDepartment of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota.
R Jeffrey KarnesDepartment of Urology, Mayo Clinic College of Medicine, Rochester, Minnesota.
Manish KohliDepartment of Oncology, Mayo Clinic College of Medicine, Rochester, Minnesota.
Jennifer J WestendorfMayo Clinic Cancer Center, Mayo Clinic College of Medicine, Rochester, Minnesota.
Benyi LiDepartment of Urology, University of Kansas Medical Center, Kansas City, Kansas.
Runzhi ZhuDepartment of Urology, University of Kansas Medical Center, Kansas City, Kansas. huang.haojie@mayo.edu runzhizhu1978@163.com xuwanhai@163.com.
Haojie HuangDepartment of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota. huang.haojie@mayo.edu runzhizhu1978@163.com xuwanhai@163.com.
Wanhai XuDepartment of Urology, The Fourth Hospital of Harbin Medical University, Harbin, Heilongjiang, China. huang.haojie@mayo.edu runzhizhu1978@163.com xuwanhai@163.com.
Mayo Clinic · US
Funding
KIDNEY DISEASES RESEARCH TRAINING PROGRAMT32DK007013 · NIDDK · MAYO CLINIC ROCHESTER · PI LIESKE, JOHN C · 1986 to 2023
$3.7MRole of proinflammatory cytokine-induced AR degradation in castration-resistant prostate cancerR01CA130908 · NCI · STATE UNIVERSITY NEW YORK STONY BROOK · PI HUANG, HAOJIE · 2010 to 2021
$3.5MRole of FOXO1 Inactivation in Prostate TumorigenesisR01CA134514 · NCI · UNIVERSITY OF MINNESOTA · PI HUANG, HAOJIE · 2009 to 2019
$3.3MRole of RUNX2 in prostate cancer intratumoral androgen synthesis and progressionR01CA193239 · NCI · MAYO CLINIC ROCHESTER · PI HUANG, HAOJIE · 2015 to 2019
$1.8MNCI NIH HHS R01 CA130908NCI NIH HHS R01 CA134514NCI NIH HHS R01 CA193239NIDDK NIH HHS T32 DK007013
Abstract
PubMed holds no abstract for this paper.
Indexed as
Abiraterone AcetateAndrogensAnimalsCell Line, TumorCore Binding Factor Alpha 1 SubunitCytochrome P-450 Enzyme InhibitorsGene Expression Regulation, NeoplasticHumansMaleMice, KnockoutProstatic Neoplasms, Castration-ResistantPTEN PhosphohydrolaseSignal TransductionSteroid 17-alpha-HydroxylaseTestosteroneTumor MicroenvironmentAbiraterone AcetateAndrogensCore Binding Factor Alpha 1 SubunitCytochrome P-450 Enzyme InhibitorsPTEN PhosphohydrolaseSteroid 17-alpha-HydroxylaseTestosterone
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.