Evidence map›Paper›PMID 29167197›Full record

ArticleThe Journal of experimental medicine2018

Rare PfCSP C-terminal antibodies induced by live sporozoite vaccination are ineffective against malaria infection.

Stephen W Scally, Rajagopal Murugan, Alexandre Bosch, Gianna Triller, Giulia Costa, Benjamin Mordmüller, Peter G Kremsner, B Kim Lee Sim, Stephen L Hoffman, Elena A Levashina and 2 more

Abstract read
In one paragraph

Article in The Journal of experimental medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed.

  1. Trial
  2. Protective near-germline antibodies to malaria elicited by RTS,S/AS01bioRxiv : the preprint server for biology · 2026
    Article
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  20. Humoral Immune Responses toInfection and drug resistance · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Stephen W ScallyProgram in Molecular Medicine, Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.
Rajagopal MuruganB Cell Immunology, German Cancer Research Center, Heidelberg, Germany.
Alexandre BoschProgram in Molecular Medicine, Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.
Gianna TrillerB Cell Immunology, German Cancer Research Center, Heidelberg, Germany.
Giulia CostaVector Biology Unit, Max Planck Institute for Infection Biology, Berlin, Germany.
Benjamin MordmüllerInstitute of Tropical Medicine and German Center for Infection Research, University of Tübingen, Tübingen, Germany.
Peter G KremsnerInstitute of Tropical Medicine and German Center for Infection Research, University of Tübingen, Tübingen, Germany.
B Kim Lee SimSanaria Inc., Rockville, MD.
Stephen L HoffmanSanaria Inc., Rockville, MD.
Elena A LevashinaVector Biology Unit, Max Planck Institute for Infection Biology, Berlin, Germany.ORCID 0000-0003-4605-906X
Hedda WardemannB Cell Immunology, German Cancer Research Center, Heidelberg, Germany h.wardemann@dkfz.de.
Jean-Philippe JulienProgram in Molecular Medicine, Hospital for Sick Children Research Institute, Toronto, Ontario, Canada jean-philippe.julien@sickkids.ca.ORCID 0000-0001-7602-3995

Funding

Plasmodium Falciparum Whole Sporozoite Malaria VaccineR44AI055229 · NIAID · SANARIA, INC. · PI HOFFMAN, STEPHEN LEV · 2005 to 2015
$10.0M
Universal Attenuated Sporozoite Vaccine and Challenge SystemR44AI058375 · NIAID · SANARIA, INC. · PI HOFFMAN, STEPHEN LEV · 2006 to 2018
$9.9M
CIHRNIAID NIH HHS R44 AI055229NIAID NIH HHS R44 AI058375
6 · The paper itself

Abstract

Antibodies against the central repeat of the

Indexed as

Amino Acid SequenceAntibodies, ProtozoanEpitopesEpitopes, T-LymphocyteMalaria, FalciparumMalaria VaccinesModels, MolecularPlasmodium falciparumProtein ConformationProtein DomainsProtozoan ProteinsRecombinant ProteinsVaccinationAntibodies, Protozoancircumsporozoite protein, ProtozoanEpitopesEpitopes, T-LymphocyteMalaria VaccinesProtozoan ProteinsRecombinant Proteins

Identifiers

PMID29167197
PMCPMC5748854

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.