Evidence map›Paper›PMID 29167177›Full record

ArticleBlood2018

Smoothened signaling in the mouse osteoblastoid lineage is required for efficient B lymphopoiesis.

Wenyan Lu, Dominic Dordai, David Huso, Stephen Desiderio

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Blood, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 87% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Current Understanding of Osteoimmunology in Certain Osteoimmune Diseases.Frontiers in cell and developmental biology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Wenyan LuDepartment of Molecular Biology and Genetics, Institute for Cell Engineering and.
Dominic DordaiDepartment of Molecular Biology and Genetics, Institute for Cell Engineering and.
David HusoDepartment of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, MD.
Stephen DesiderioDepartment of Molecular Biology and Genetics, Institute for Cell Engineering and.
Johns Hopkins Medicine · US

Funding

Non-cell-autonomous hedgehog signaling in B lymphopoiesisR01DK099188 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI DESIDERIO, STEPHEN V · 2014 to 2016
$729k
NIDDK NIH HHS R01 DK099188
6 · The paper itself

Abstract

The stromal signals that promote B lymphopoiesis remain poorly understood. Hedgehog (Hh) signaling promotes B lymphopoiesis in a non-cell-autonomous fashion in vitro, and depletion of the Hh effector Smoothened (Smo) from stromal cells is associated with the loss of osteoblastoid markers. These observations suggested that Hh signaling in the osteoblastoid lineage promotes B lymphopoiesis in vivo. To test this, we employed a mouse model for conditional ablation of

Indexed as

Cell LineageLymphopoiesisSignal TransductionAnimalsB-LymphocytesBone MarrowHedgehog ProteinsMice, TransgenicOsteoblastsSmoothened ReceptorHedgehog ProteinsSmoothened ReceptorSmo protein, mouse

Identifiers

PMID29167177
PMCPMC5774210
OpenAlexW2769356084

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.