Evidence map›Paper›PMID 29167165›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2018

Long-term high-altitude hypoxia influences pulmonary arterial L-type calcium channel-mediated Ca

Christine P Shen, Monica Romero, Alexander Brunelle, Craig Wolfe, Abigail Dobyns, Michael Francis, Mark S Taylor, Jose L Puglisi, Lawrence D Longo, Lubo Zhang and 2 more

Open access · bronzeAbstract readComparative Study
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Long-Term Hypoxia Negatively Influences CaFrontiers in physiology · 2021
    Article
  8. Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Christine P ShenLawrence D. Longo, MD Center for Perinatal Biology, Loma Linda University School of Medicine , Loma Linda, California.
Monica RomeroAdvanced Imaging and Microscopy Core, Loma Linda University School of Medicine , Loma Linda, California.
Alexander BrunelleLawrence D. Longo, MD Center for Perinatal Biology, Loma Linda University School of Medicine , Loma Linda, California.
Craig WolfeLawrence D. Longo, MD Center for Perinatal Biology, Loma Linda University School of Medicine , Loma Linda, California.
Abigail DobynsLawrence D. Longo, MD Center for Perinatal Biology, Loma Linda University School of Medicine , Loma Linda, California.
Michael FrancisDepartment of Physiology, University of South Alabama College of Medicine , Mobile, Alabama.
Mark S TaylorDepartment of Physiology, University of South Alabama College of Medicine , Mobile, Alabama.
Jose L PuglisiDepartment of Biostatistics, California Northstate University School of Medicine , Elk Grove, California.
Lawrence D LongoLawrence D. Longo, MD Center for Perinatal Biology, Loma Linda University School of Medicine , Loma Linda, California.
Lubo ZhangLawrence D. Longo, MD Center for Perinatal Biology, Loma Linda University School of Medicine , Loma Linda, California.
Christopher G WilsonLawrence D. Longo, MD Center for Perinatal Biology, Loma Linda University School of Medicine , Loma Linda, California.
Sean M WilsonLawrence D. Longo, MD Center for Perinatal Biology, Loma Linda University School of Medicine , Loma Linda, California.
Loma Linda University · USUniversity of South Alabama · USCalifornia Northstate University · US

Funding

Uterine vascular responses to pregnancy and long term hypoxemiaP01HD031226 · NICHD · LOMA LINDA UNIVERSITY · PI LONGO, LAWRENCE D · 1995 to 2014
$21.4M
Uterine Vascular Adaptation to Pregnancy and Chronic HypoxiaP01HD083132 · NICHD · LOMA LINDA UNIVERSITY · PI DUCSAY, CHARLES A · 2016 to 2020
$6.3M
FETAL OXYGENATION AND PLACENTAL GAS EXCHANGER01HD003807 · NICHD · LOMA LINDA UNIVERSITY · PI GOYAL, RAVI · 1985 to 2015
$4.1M
Uterine Arterial Spontaneous Transient Outward Currents in PregnancyR01HL137649 · NHLBI · LOMA LINDA UNIVERSITY · PI ZHANG, LUBO · 2017 to 2020
$1.6M
TRPC4-mediated calcium signals accelerate vascular remodeling in pulmonary arterial hypertensionK25HL136869 · NHLBI · UNIVERSITY OF SOUTH ALABAMA · PI FRANCIS, CHRISTOPHER MICHAEL · 2017 to 2021
$798k
NHLBI NIH HHS K25 HL136869NHLBI NIH HHS R01 HL137649NICHD NIH HHS P01 HD031226NICHD NIH HHS P01 HD083132NICHD NIH HHS R01 HD003807
6 · The paper itself

Abstract

Long-term hypoxia (LTH) has a profound effect on pulmonary arterial vasoconstriction in the fetus and adult. Dysregulation in Ca

Indexed as

Calcium SignalingVasoconstrictionAltitude SicknessAnimalsCalciumCalcium Channel AgonistsCalcium Channel BlockersCalcium Channels, L-TypeDisease Models, AnimalFemaleFetal HeartGestational AgeMembrane PotentialsMyocytes, CardiacPregnancyPulmonary ArteryCalciumCalcium Channel AgonistsCalcium Channel BlockersCalcium Channels, L-Typearterial myocytesCa2+ oscillationsCa2+ sparkscontractionL-type Ca2+ channels

Identifiers

PMID29167165
PMCPMC5899247
OpenAlexW2768555383

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.