Evidence map›Paper›PMID 29167045›Full record

ArticleJournal of psychosomatic research2017

Long-term caregiving is associated with impaired cardiovagal baroreflex.

Kevin K Wu, Taylor Bos, Brent T Mausbach, Milos Milic, Michael G Ziegler, Roland von Känel, Matthew A Allison, Joel E Dimsdale, Paul J Mills, Sonia Ancoli-Israel and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychosomatic research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Kevin K WuFrank H. Netter MD School of Medicine at Quinnipiac University, United States.
Taylor BosDepartment of Psychiatry, University of California, San Diego, United States; Joint Doctoral Program in Clinical Psychology, San Diego State University/University of California, San Diego, United States.
Brent T MausbachDepartment of Psychiatry, University of California, San Diego, United States. Electronic address: bmausbach@ucsd.edu.
Milos MilicDepartment of Medicine, University of California, San Diego, United States.
Michael G ZieglerDepartment of Medicine, University of California, San Diego, United States.
Roland von KänelDepartment of Psychiatry, University of California, San Diego, United States; Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Switzerland.
Matthew A AllisonDepartment of Family and Preventive Medicine, University of California, San Diego, United States.
Joel E DimsdaleDepartment of Psychiatry, University of California, San Diego, United States.
Paul J MillsDepartment of Psychiatry, University of California, San Diego, United States; Department of Family and Preventive Medicine, University of California, San Diego, United States.
Sonia Ancoli-IsraelDepartment of Psychiatry, University of California, San Diego, United States; Department of Medicine, University of California, San Diego, United States.
Thomas L PattersonDepartment of Psychiatry, University of California, San Diego, United States.
Igor GrantDepartment of Psychiatry, University of California, San Diego, United States.
University of California, San Diego · USQuinnipiac University · USSan Diego State University · US

Funding

ALZHEIMER CAREGIVER COPING--MENTAL AND PHYSICAL HEALTHR01AG015301 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GRANT, IGOR · 1997 to 2011
$7.6M
Alzheimer Caregiver Coping: Mental and Physical HealthRF1AG015301 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GRANT, IGOR, MAUSBACH, BRENT T · 2014 to 2014
$4.4M
Mobile, Web-based Behavioral Intervention for Improving Caregiver Well-beingR01AG061941 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MAUSBACH, BRENT T · 2018 to 2022
$2.6M
UCSD Medical Student Summer Aging Research TrainingT35AG026757 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Benjamin Hyun Han, Ellen Eun-Ok Lee · 2005 to 2026
$2.2M
NIA NIH HHS R01 AG015301NIA NIH HHS R01 AG061941NIA NIH HHS RF1 AG015301NIA NIH HHS T35 AG026757
6 · The paper itself

Abstract

objectiveCaregiving stress is associated with increased risk of cardiovascular disease (CVD). Inability to adequately regulate blood pressure is a possible underlying mechanism explaining this risk. We examined the relationship between length of caregiving and cardiovagal baroreflex sensitivity (cBRS) to better understand the link between caregiving and CVD risk.

methodsA total of 146 elderly individuals (≥55years) participated in this study, of whom 96 were providing in-home care to a spouse with dementia and 50 were healthy controls married to a non-demented spouse (i.e., non-caregivers). Among the caregivers, 56 were short-term caregivers (caring<4years) and 40 were long-term caregivers (caring≥4years). A multiple linear regression model, with contrast codes comparing short and long-term caregivers with non-caregivers was used to understand relationships between chronic caregiving and cBRS.

resultsAfter controlling for relevant demographic and health characteristics, mean±SE log transformed cBRS for non-caregivers was 0.971±0.029. Relative to non-caregivers, the long-term caregivers had significantly impaired cBRS (0.860±0.033; p=0.013). However, mean cBRS for short-term caregivers did not significant differ from non-caregivers (0.911±0.028; p=0.144).

conclusionThese results suggest that long-term caregiving stress is associated with an impaired cBRS. Accumulation of stress from years of caregiving could result in worse cBRS function, which could be a mechanistic explanation for the correlation between caregiving stress and the increased risk of CVD.

Indexed as

AgedBaroreflexCardiovascular DiseasesCaregiversFemaleHumansMaleStress, PsychologicalAlzheimer'sBaroreceptor reflexCardiovascular diseaseHeart diseaseLife stress

Identifiers

PMID29167045
PMCPMC5726529
OpenAlexW2761134827

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.