Evidence map›Paper›PMID 29166944›Full record

ArticleArthritis research & therapy2017

Targeting of vascular adhesion protein-1 by positron emission tomography visualizes sites of inflammation in Borrelia burgdorferi-infected mice.

Riikka Siitonen, Annukka Pietikäinen, Heidi Liljenbäck, Meeri Käkelä, Mirva Söderström, Sirpa Jalkanen, Jukka Hytönen, Anne Roivainen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arthritis research & therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. Trial
  2. Borrelia surface proteins: new horizons in Lyme disease diagnosis.Applied microbiology and biotechnology · 2025
    Review
  3. Article
  4. Vascular adhesion protein-1-targeted PET imaging in autoimmune myocarditis.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023
    Article
  5. Persistent Borrelia burgdorferiClinical microbiology reviews · 2022
    Review
  6. First-in-Humans Study ofJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2021
    Article
  7. Kinetic Modelling of [Molecules (Basel, Switzerland) · 2019
    Article
  8. Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2019
    Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Riikka SiitonenTurku PET Centre, University of Turku, Kiinamyllynkatu 4-8, FI-20520, Turku, Finland.
Annukka PietikäinenInstitute of Biomedicine, University of Turku, Kiinamyllynkatu 10, FI-20520, Turku, Finland.
Heidi LiljenbäckTurku PET Centre, University of Turku, Kiinamyllynkatu 4-8, FI-20520, Turku, Finland.
Meeri KäkeläTurku PET Centre, University of Turku, Kiinamyllynkatu 4-8, FI-20520, Turku, Finland.
Mirva SöderströmDepartment of Pathology, Turku University Hospital, Kiinamyllynkatu 10, FI-20520, Turku, Finland.
Sirpa JalkanenInstitute of Biomedicine, University of Turku, Kiinamyllynkatu 10, FI-20520, Turku, Finland.
Jukka HytönenInstitute of Biomedicine, University of Turku, Kiinamyllynkatu 10, FI-20520, Turku, Finland.
Anne RoivainenTurku PET Centre, University of Turku, Kiinamyllynkatu 4-8, FI-20520, Turku, Finland. anne.roivainen@utu.fi.
University of Turku · FITurku University Hospital · FITurku PET Centre · FI

Funding

Academy of Finland 258814Academy of Finland 292701State Research Funding (ERVA) 13856
6 · The paper itself

Abstract

backgroundIn the present study, we sought to evaluate the feasibility of targeting vascular adhesion protein-1 (VAP-1) by positron emission tomography (PET) for the longitudinal quantitative assessment of Borrelia burgdorferi infection-induced inflammation in mice.

methodsMice with B. burgdorferi infection-induced arthritis were studied. During a 7-week follow-up period, the progression of arthritis was monitored weekly with

resultsExplicit joint swelling and

conclusionsThe present study showed that

Indexed as

Amine Oxidase (Copper-Containing)AnimalsAnti-Bacterial AgentsArthritisBorrelia burgdorferiCeftriaxoneCell Adhesion MoleculesDisease Models, AnimalGallium RadioisotopesHost-Pathogen InteractionsHumansImmunohistochemistryLyme DiseaseMicePositron Emission Tomography Computed TomographySialic Acid Binding Immunoglobulin-like LectinsAmine Oxidase (Copper-Containing)Anti-Bacterial AgentsCeftriaxoneCell Adhesion MoleculesGallium Radioisotopessemicarbazide-sensitive amine oxidase-vascular adhesion protein-1, mouseSialic Acid Binding Immunoglobulin-like LectinsarthritisBorrelia burgdorferiInfectionInflammationLyme borreliosisPETSiglec-9VAP-1

Identifiers

PMID29166944
PMCPMC5700622
OpenAlexW2770412163

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.