Evidence map›Paper›PMID 29166854›Full record

ArticleBMC anesthesiology2017

A single dose of dezocine suppresses emergence agitation in preschool children anesthetized with sevoflurane-remifentanil.

Li-Jun An, Yang Zhang, Zheng Su, Xian-Long Zhang, Hai-Lin Liu, Zhi-Jie Zhang, Jian-Lin Hu, Shi-Tong Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC anesthesiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.6field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Li-Jun AnDepartment of Anesthesiology, Shanghai General Hospital of Nanjing Medical University, University, No. 100 Haining Road, Shanghai, 200030, China.
Yang ZhangDepartment of Anesthesiology, Huai'an First People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, China.
Zheng SuDepartment of Anesthesiology, Huai'an First People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, China.
Xian-Long ZhangDepartment of Anesthesiology, Huai'an First People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, China.
Hai-Lin LiuDepartment of Anesthesiology, Huai'an First People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, China.
Zhi-Jie ZhangDepartment of Anesthesiology, Huai'an First People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, China.
Jian-Lin HuDepartment of Anesthesiology, Shanghai General Hospital of Nanjing Medical University, University, No. 100 Haining Road, Shanghai, 200030, China.
Shi-Tong LiDepartment of Anesthesiology, Shanghai General Hospital of Nanjing Medical University, University, No. 100 Haining Road, Shanghai, 200030, China. shlishitong@126.com.ORCID http://orcid.org/0000-0003-3049-8789
Huaian First People’s Hospital · CNShanghai Medical College of Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEmergence agitation (EA) is a common phenomenon in preschool children during emergence from general anesthesia. This study evaluated the safety and efficacy of dezocine for emergence agitation in preschool children anesthetized with sevoflurane-remifentanil.

methodsA total of 100 preschool children, scheduled for elective laparoscopic repair of an inguinal hernia by high ligation of the hernia sac under sevoflurane-remifentanil anesthesia were randomized into two groups: Group C (n = 50) received Ringer's lactate 10 mL and Group D received Ringer's lactate 10 mL containing dezocine 0.1 mg/kg, postoperatively.

resultsIncidence of EA, defined as a score ≥ 3 on Aono's four point scale or Pediatric Anesthesia Emergence Delirium (PAED) score ≥ 10 in the PACU (10% vs. 76%) and the percentage of patients with severe EA (PAED score ≥ 13) (12% vs. 76%) were significantly lower in Group D compared to Group C (P < 0.05). Mean Children and Infants Postoperative Pain Scale (CHIPPS) score was significantly lower in Group D compared to Group C (1.2 ± 0.5 vs. 5.2 ± 0.6; P < 0.05). Patients need for fentanyl (18% vs. 4%) or propofol rescue (20% vs. 0) was significantly greater in Group C compared to Group D. No significant differences in other relative aspects after surgery between groups.

conclusionAdministration of dezocine 0.1 mg/kg decreased the incidence and severity of EA in preschool children that had undergone laparoscopic repair of an inguinal hernia by high ligation of the hernia sac under sevoflurane-remifentanil anesthesia.

trial registrationA single dose of dezocine suppresses emergence agitation in preschool children anesthetized with sevoflurane-remifentanil effectively: A double-blind, prospective, randomized, controlled study, Chinese Clinical Trial Registry (ID: ChiCTR-IOR-16010033), retrospectively registered on November 21, 2016.

Indexed as

Anesthesia Recovery PeriodAnalgesics, OpioidAnesthetics, InhalationBridged Bicyclo Compounds, HeterocyclicChild, PreschoolDouble-Blind MethodFemaleHumansMaleMethyl EthersPiperidinesPostoperative ComplicationsProspective StudiesPsychomotor AgitationRemifentanilSevofluraneAnalgesics, OpioidAnesthetics, InhalationBridged Bicyclo Compounds, HeterocyclicdezocineMethyl EthersPiperidinesRemifentanilSevofluraneTetrahydronaphthalenesDezocineEmergence agitationPreschool childrenSevoflurane-remifentanil

Identifiers

PMID29166854
PMCPMC5700567
OpenAlexW2769821829

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.