Evidence map›Paper›PMID 29166841›Full record

ArticleVirulence2018

Noninvasive optical and nuclear imaging of Staphylococcus-specific infection with a human monoclonal antibody-based probe.

Francisco Romero Pastrana, John M Thompson, Marjolein Heuker, Hedzer Hoekstra, Carly A Dillen, Roger V Ortines, Alyssa G Ashbaugh, Julie E Pickett, Matthijs D Linssen, Nicholas M Bernthal and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virulence, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Review
  2. Imaging ofbioRxiv : the preprint server for biology · 2026
    Article
  3. Review
  4. The secreted proteasesVirulence · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. In Vivo Detection ofInternational journal of biomedical imaging · 2024
    Article
  10. Radiometal chelators for infection diagnostics.Frontiers in nuclear medicine · 2023
    Article
  11. Article
  12. In vitro and in vivo methods to study bacterial colonization of hydrogel dermal fillers.Journal of biomedical materials research. Part B, Applied biomaterials · 2022
    Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Novel in vivo mouse model of shoulder implant infection.Journal of shoulder and elbow surgery · 2020
    Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Francisco Romero Pastranaa Department of Medical Microbiology , University of Groningen, University Medical Center Groningen , Hanzeplein 1, Groningen , RB , The Netherlands.
John M Thompsonb Department of Orthopaedic Surgery , Johns Hopkins University School of Medicine , Baltimore , MD , USA.
Marjolein Heukera Department of Medical Microbiology , University of Groningen, University Medical Center Groningen , Hanzeplein 1, Groningen , RB , The Netherlands.
Hedzer Hoekstraa Department of Medical Microbiology , University of Groningen, University Medical Center Groningen , Hanzeplein 1, Groningen , RB , The Netherlands.
Carly A Dillenc Department of Dermatology , Johns Hopkins University School of Medicine , Baltimore , MD , USA.
Roger V Ortinesc Department of Dermatology , Johns Hopkins University School of Medicine , Baltimore , MD , USA.
Alyssa G Ashbaughc Department of Dermatology , Johns Hopkins University School of Medicine , Baltimore , MD , USA.
Julie E Pickettd Division of Nuclear Medicine and Molecular Imaging, Department of Radiology and Radiological Science , Johns Hopkins University School of Medicine , Baltimore , MD , USA.
Matthijs D Linssene Department of Gastroentrology and Hepatology , University of Groningen, University Medical Center Groningen , Hanzeplein 1, Groningen , RB , The Netherlands.
Nicholas M Bernthalg Department of Orthopaedic Surgery , David Geffen School of Medicine at the University of California, Los Angeles Medical Center , Santa Monica , CA , USA.
Kevin P Francisg Department of Orthopaedic Surgery , David Geffen School of Medicine at the University of California, Los Angeles Medical Center , Santa Monica , CA , USA.
Girbe Buista Department of Medical Microbiology , University of Groningen, University Medical Center Groningen , Hanzeplein 1, Groningen , RB , The Netherlands.
Marleen van Oostena Department of Medical Microbiology , University of Groningen, University Medical Center Groningen , Hanzeplein 1, Groningen , RB , The Netherlands.
Gooitzen M van Dami Department of Surgery , Nuclear Medicine and Molecular Imaging and Intensive Care, University of Groningen, University Medical Center Groningen , Hanzeplein 1, Groningen , RB , The Netherlands.
Daniel L J Thorekd Division of Nuclear Medicine and Molecular Imaging, Department of Radiology and Radiological Science , Johns Hopkins University School of Medicine , Baltimore , MD , USA.
Lloyd S Millerb Department of Orthopaedic Surgery , Johns Hopkins University School of Medicine , Baltimore , MD , USA.
Jan Maarten van Dijla Department of Medical Microbiology , University of Groningen, University Medical Center Groningen , Hanzeplein 1, Groningen , RB , The Netherlands.

Funding

Training In Orthopaedic Team ScienceT32AR067708 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI JONES, LYNNE C., SHAFIQ, BABAR · 2015 to 2024
$2.0M
STAT3-mediated immunity to Staphylococcus aureus in skinR01AR069502 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI ARCHER, NATHAN K. · 2016 to 2020
$1.8M
Modifying and Delivering Antimicrobials to Prevent Orthopaedic Implant InfectionsK08AR069112 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BERNTHAL, NICHOLAS M. · 2016 to 2019
$704k
NIAMS NIH HHS K08 AR069112NIAMS NIH HHS R01 AR069502NIAMS NIH HHS T32 AR067708
6 · The paper itself

Abstract

Staphylococcus aureus infections are a major threat in healthcare, requiring adequate early-stage diagnosis and treatment. This calls for novel diagnostic tools that allow noninvasive in vivo detection of staphylococci. Here we performed a preclinical study to investigate a novel fully-human monoclonal antibody 1D9 that specifically targets the immunodominant staphylococcal antigen A (IsaA). We show that 1D9 binds invariantly to S. aureus cells and may further target other staphylococcal species. Importantly, using a human post-mortem implant model and an in vivo murine skin infection model, preclinical feasibility was demonstrated for 1D9 labeled with the near-infrared fluorophore IRDye800CW to be applied for direct optical imaging of in vivo S. aureus infections. Additionally,

Indexed as

AnimalsAntibodies, MonoclonalAntigens, BacterialCadaverDisease Models, AnimalFluorescent DyesHumansMiceOptical ImagingStaphylococcal InfectionsStaphylococcal Skin InfectionsStaphylococcus aureusAntibodies, MonoclonalAntigens, BacterialFluorescent Dyes89Zrhuman monoclonal antibodyimmunodominant staphylococcal antigen AIsaAPETStaphylococcus aureus

Identifiers

PMID29166841
PMCPMC5955194

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.