Evidence map›Paper›PMID 29166765›Full record

ArticleThe Journal of organic chemistry2017

Metal-free, Regio-, and Stereo-Controlled Hydrochlorination and Hydrobromination of Ynones and Ynamides.

Xiaojun Zeng, Zhichao Lu, Shiwen Liu, Gerald B Hammond, Bo Xu

Abstract read
In one paragraph

Article in The Journal of organic chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. HCl•DMPU-Assisted One-pot and Metal-free Conversion of Aldehydes to Nitriles.Green chemistry : an international journal and green chemistry resource : GC · 2020
    Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xiaojun ZengCollege of Chemistry, Chemical Engineering and Biotechnology, Donghua University , 2999 North Renmin Lu, Shanghai 201620, China.
Zhichao LuDepartment of Chemistry, University of Louisville , Louisville, Kentucky 40292, United States.
Shiwen LiuCollege of Chemistry, Chemical Engineering and Biotechnology, Donghua University , 2999 North Renmin Lu, Shanghai 201620, China.
Gerald B HammondDepartment of Chemistry, University of Louisville , Louisville, Kentucky 40292, United States.ORCID 0000-0002-9814-5536
Bo XuCollege of Chemistry, Chemical Engineering and Biotechnology, Donghua University , 2999 North Renmin Lu, Shanghai 201620, China.

Funding

Nucleophilic Halogenation ReagentsR01GM121660 · NIGMS · UNIVERSITY OF LOUISVILLE · PI HAMMOND, GERALD B · 2017 to 2021
$1.5M
NIGMS NIH HHS R01 GM121660
6 · The paper itself

Abstract

We developed an atom-economical and metal-free method for the regio- and stereo-selective hydrohalogenation of ynones and ynamides using easy to handle DMPU/HX (X = Br or Cl) reagents. The reaction operates under mild conditions and a range of functional groups is well tolerated. We propose that the hydrohalogenation of ynones gives the anti-addition products via a concerted multimolecular Ad

Indexed as

HalogenationAmidesKetonesMetalsStereoisomerismAmidesKetonesMetals

Identifiers

PMID29166765
PMCPMC5735994

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.