ArticlePloS one2017
Sex-specific influences of mtDNA mitotype and diet on mitochondrial functions and physiological traits in Drosophila melanogaster.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Article
- Support for Y-compensation of mother's curse affecting lifespan in Drosophila melanogaster.Heredity · 2024Article
- Mitonuclear effects on sex ratio persist across generations in interpopulation hybrids.Journal of evolutionary biology · 2024Article
- Mother's Curse effects on lifespan and aging.Frontiers in aging · 2024Review
- Review
- Investigating the Impact of a Curse: Diseases, Population Isolation, Evolution and the Mother's Curse.Genes · 2022Review
- Food deprivation exposes sex-specific trade-offs between stress tolerance and life span in the copepodEcology and evolution · 2022Article
- Mitonuclear interactions alter sex-specific longevity in a species without sex chromosomes.Proceedings. Biological sciences · 2021Article
- Sex-specific effects of mitochondrial haplotype on metabolic rate inPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- A role for triglyceride lipase brummer in the regulation of sex differences in Drosophila fat storage and breakdown.PLoS biology · 2020Article
- Drosophila Flies in the Face of Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Article
- Sex and age specific reduction in stress resistance and mitochondrial DNA copy number in Drosophila melanogaster.Scientific reports · 2019Article
- The cuticle inward barrier inPeerJ · 2019Article
- Sex differences inCurrent opinion in physiology · 2018Article
- Genotype to phenotype: Diet-by-mitochondrial DNA haplotype interactions drive metabolic flexibility and organismal fitness.PLoS genetics · 2018Review
- Mitotype Interacts With Diet to Influence Longevity, Fitness, and Mitochondrial Functions in Adult FemaleFrontiers in genetics · 2018Article
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Here we determine the sex-specific influence of mtDNA type (mitotype) and diet on mitochondrial functions and physiology in two Drosophila melanogaster lines. In many species, males and females differ in aspects of their energy production. These sex-specific influences may be caused by differences in evolutionary history and physiological functions. We predicted the influence of mtDNA mutations should be stronger in males than females as a result of the organelle's maternal mode of inheritance in the majority of metazoans. In contrast, we predicted the influence of diet would be greater in females due to higher metabolic flexibility. We included four diets that differed in their protein: carbohydrate (P:C) ratios as they are the two-major energy-yielding macronutrients in the fly diet. We assayed four mitochondrial function traits (Complex I oxidative phosphorylation, reactive oxygen species production, superoxide dismutase activity, and mtDNA copy number) and four physiological traits (fecundity, longevity, lipid content, and starvation resistance). Traits were assayed at 11 d and 25 d of age. Consistent with predictions we observe that the mitotype influenced males more than females supporting the hypothesis of a sex-specific selective sieve in the mitochondrial genome caused by the maternal inheritance of mitochondria. Also, consistent with predictions, we found that the diet influenced females more than males.
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