Evidence map›Paper›PMID 29166605›Full record

ArticleCell reports2017

L-Type Voltage-Gated Ca

Brian G Hiester, Ashley M Bourke, Brooke L Sinnen, Sarah G Cook, Emily S Gibson, Katharine R Smith, Matthew J Kennedy

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 35 citations in OpenAlex.

  1. Review
  2. Signaling by intracellular βCell reports · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. The CaNeuropharmacology · 2022
    Article
  12. Article
  13. Article
  14. Loss of CaProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  15. Article
  16. APOE4 Affects Basal and NMDAR-Mediated Protein Synthesis in Neurons by Perturbing Calcium Homeostasis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Brian G HiesterDepartment of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO 80045, USA.
Ashley M BourkeDepartment of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO 80045, USA.
Brooke L SinnenDepartment of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO 80045, USA.
Sarah G CookDepartment of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO 80045, USA.
Emily S GibsonDepartment of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO 80045, USA.
Katharine R SmithDepartment of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO 80045, USA.
Matthew J KennedyDepartment of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO 80045, USA. Electronic address: matthew.kennedy@ucdenver.edu.
University of Colorado Anschutz Medical Campus · US

Funding

PREDOCTORAL TRAINING PROGRAM IN PHARMACOLOGYT32GM007635 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI DELL'ACQUA, MARK L · 1985 to 2023
$6.1M
Mechanisms of dendritic exocytosisR01NS082271 · NINDS · UNIVERSITY OF COLORADO DENVER · PI KENNEDY, MATTHEW J · 2013 to 2017
$1.7M
Mechanisms of Beta Amyloid-Induced Synaptic DysfunctionF31NS100403 · NINDS · UNIVERSITY OF COLORADO DENVER · PI SINNEN, BROOKE · 2017 to 2018
$54k
NIGMS NIH HHS T32 GM007635NINDS NIH HHS F31 NS100403NINDS NIH HHS R01 NS082271
6 · The paper itself

Abstract

The repertoire and abundance of proteins displayed on the surface of neuronal dendrites are tuned by regulated fusion of recycling endosomes (REs) with the dendritic plasma membrane. While this process is critical for neuronal function and plasticity, how synaptic activity drives RE fusion remains unexplored. We demonstrate a multistep fusion mechanism that requires Ca

Indexed as

AnimalsCells, CulturedDendritesEndosomesLong-Term PotentiationRats, Sprague-DawleyReceptors, AMPAReceptors, N-Methyl-D-AspartateSynapsesReceptors, AMPAReceptors, N-Methyl-D-AspartateAMPA receptordendritedendritic spineexocytosislong-term potentiationL-type voltage-gated calcium channelNMDA receptorrecycling endosomesynapsesynaptic plasticity

Identifiers

PMID29166605
PMCPMC6466620
OpenAlexW2768593100

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.