ArticleNeuropsychologia2020
Neural correlates of improvements in personality and behavior following a neurological event.
Article in Neuropsychologia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.
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Who cites it
7 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The neural correlates of well-being: A systematic review of the human neuroimaging and neuropsychological literature.Cognitive, affective & behavioral neuroscience · 2019Pooled it
- Gender and Hemispheric Asymmetries in Acquired Sociopathy.Frontiers in psychology · 2019Pooled it
- Unsupervised mapping of causal relations between brain lesions and behavior.bioRxiv : the preprint server for biology · 2025Article
- Frontal damage and resolution of schizophrenia in a patient with self-inflicted gunshot wound: a case report.BMC neurology · 2025Article
- Large-scale lesion symptom mapping of depression identifies brain regions for risk and resilience.Brain : a journal of neurology · 2023Article
- Lesions in different prefrontal sectors are associated with different types of acquired personality disturbances.Cortex; a journal devoted to the study of the nervous system and behavior · 2022Observational
- Assessing the Effects of Healthy and Neuropathological Aging on Personality with the Iowa Scales of Personality Change.Developmental neuropsychology · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Research on changes in personality and behavior following brain damage has focused largely on negative outcomes, such as increased irritability, moodiness, and social inappropriateness. However, clinical observations suggest that some patients may actually show positive personality and behavioral changes following a neurological event. In the current work, we investigated neuroanatomical correlates of positive personality and behavioral changes following a discrete neurological event (e.g., stroke, benign tumor resection). Patients (N = 97) were rated by a well-known family member or friend on five domains of personality and behavior: social behavior, irascibility, hypo-emotionality, distress, and executive functioning. Ratings were acquired during the chronic epoch of recovery, when psychological status was stabilized. We identified patients who showed positive changes in personality and behavior in one or more domains of functioning. Lesion analyses indicated that positive changes in personality and behavior were most consistently related to damage to the bilateral frontal polar regions and the right anterior dorsolateral prefrontal region. These findings support the conclusion that improvements in personality and behavior can occur after a neurological event, and that such changes have systematic neuroanatomical correlates. Patients who showed positive changes in personality and behavior following a neurological event were rated as having more disturbed functioning prior to the event. Our study may be taken as preliminary evidence that improvements in personality and behavior following a neurological event may involve dampening of (premorbidly) more extreme expressions of emotion.
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