ArticlePediatric research2018
Effect of iron overload on impaired fertility in male patients with transfusion-dependent beta-thalassemia.
Article in Pediatric research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Iron overload disorders in adults: a comprehensive review of gonadal function, reproductive, and sexual health.Human reproduction update · 2026Pooled it
- The role of iron in normal and impaired testicular function.Andrology · 2026Review
- Excess copper exposure and male reproductive toxicity: molecular mechanisms and potential interventions.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025Review
- Impact of sickle cell anaemia on reproductive health: a narrative review.Reproductive health · 2025Review
- Germ Cell Dysfunction is Universal in Adolescent Male Patients with β-thalassemia Following Earlier Successful Hematopoietic Stem Cell TransplantationJournal of clinical research in pediatric endocrinology · 2025Article
- Male reproductive phenotype alterations in heterozygous β-globin gene knockout thalassemia (BKO) mice as a model for β-thalassemia patients.Scientific reports · 2025Article
- The mechanism of oxidative stress in asthenozoospermia and antioxidant strategies: a review.Frontiers in endocrinology · 2025Review
- Beta-Thalassemia and Male Infertility: Unraveling the Oxidative Stress Connection-An Up-to-Date Review.Diagnostics (Basel, Switzerland) · 2024Review
- Metabolomics reveals that ferroptosis participates in bisphenol A-induced testicular injury.Heliyon · 2024Article
- The effect of red blood cell disorders on male fertility and reproductive health.Nature reviews. Urology · 2024Review
- Beet leaf (beta vulgaris L.) extract attenuates iron-induced testicular toxicity: Experimental and computational approach.Heliyon · 2023Article
- Analysis of sperm separation protocols for isolating cryopreserved human spermatozoa.Reproduction & fertility · 2023Article
- A Short Review on Growth and Endocrine Long-term Complications in Children and Adolescents with β-Thalassemia Major: Conventional Treatment versus Hematopoietic Stem Cell Transplantation.Acta bio-medica : Atenei Parmensis · 2022Review
- New Entity-Thalassemic Endocrine Disease: Major Beta-Thalassemia and Endocrine Involvement.Diagnostics (Basel, Switzerland) · 2022Review
- Effects of Ferroptosis on Male Reproduction.International journal of molecular sciences · 2022Review
- Testicular Tissue Banking for Fertility Preservation in Young Boys: Which Patients Should Be Included?Frontiers in endocrinology · 2022Review
- Article
- Effects of Environmental and Pathological Hypoxia on Male Fertility.Frontiers in cell and developmental biology · 2021Review
- Indicators of male fertility potential in adult patients with beta-thalassemia major: a comparative study between patients undergone allogeneic stem cell transplantation and transfusion-dependent patients.Fertility research and practice · 2020Article
- Exenatide reduces oxidative stress and cell death in testis in iron overload rat model.Experimental and therapeutic medicine · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BackgroundTo investigate the fertility of male patients with transfusion-dependent beta-thalassemia, and to use magnetic resonance imaging (MRI) as a novel method to assess the iron overload status of testis in such patients.MethodsTwenty-one male patients with transfusion-dependent beta-thalassemia and five normal male controls enrolled in this study. Hormonal profiles, iron levels, MRI testicular dimension, MRI T2 values, parameters for sperm quality, and sperm DNA fragmentation (SDF) of participants were measured.ResultsThe MRI T2 values of the testis were significantly lower in transfusion-dependent beta-thalassemia patients than in normal controls (P=0.027), and they correlated to serum ferritin levels in all enrolled subjects (R
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.