Evidence map›Paper›PMID 29166129›Full record

ArticleThe British journal of radiology2018

Initial clinical observations of intra- and interfractional motion variation in MR-guided lung SBRT.

David H Thomas, Anand Santhanam, Amar U Kishan, Minsong Cao, James Lamb, Yugang Min, Dylan O'Connell, Yingli Yang, Nzhde Agazaryan, Percy Lee and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The British journal of radiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 61 citations in OpenAlex.

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  16. Head and neck radiotherapy on the MR linac: a multicenter planning challenge amongst MRIdian platform users.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

David H Thomas1 Department of Radiation Oncology, University of Colorado School of Medicine , Aurora, CO , USA.
Anand Santhanam2 Department of Radiation Oncology, University of California , Los Angeles, CA , USA.
Amar U Kishan2 Department of Radiation Oncology, University of California , Los Angeles, CA , USA.
Minsong Cao2 Department of Radiation Oncology, University of California , Los Angeles, CA , USA.
James Lamb2 Department of Radiation Oncology, University of California , Los Angeles, CA , USA.
Yugang Min2 Department of Radiation Oncology, University of California , Los Angeles, CA , USA.
Dylan O'Connell2 Department of Radiation Oncology, University of California , Los Angeles, CA , USA.
Yingli Yang2 Department of Radiation Oncology, University of California , Los Angeles, CA , USA.
Nzhde Agazaryan2 Department of Radiation Oncology, University of California , Los Angeles, CA , USA.
Percy Lee2 Department of Radiation Oncology, University of California , Los Angeles, CA , USA.
Daniel Low2 Department of Radiation Oncology, University of California , Los Angeles, CA , USA.
University of California, Los Angeles · USUniversity of Colorado Denver · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate variations in intra- and interfractional tumour motion, and the effect on internal target volume (ITV) contour accuracy, using deformable image registration of real-time two-dimensional-sagittal cine-mode MRI acquired during lung stereotactic body radiation therapy (SBRT) treatments.

methodsFive lung tumour patients underwent free-breathing SBRT treatments on the ViewRay system, with dose prescribed to a planning target volume (defined as a 3-6 mm expansion of the 4DCT-ITV). Sagittal slice cine-MR images (3.5 × 3.5 mm

resultsDifferences were observed in the magnitude of median tumour displacement between days of treatments. MR-ITV

conclusionAn ITV offers a "snapshot" of breathing motion for the brief period of time the tumour is imaged on a specific day. Real-time MRI over prolonged periods of time and over multiple treatment fractions shows that ITV size varies. Further work is required to investigate the dosimetric effect of these results. Advances in knowledge: Five lung tumour patients underwent free-breathing MRI-guided SBRT treatments, and their tumours tracked using deformable registration of cine-mode MRI. The results indicate that variability of both intra- and interfractional breathing amplitude should be taken into account during planning of lung radiotherapy.

Indexed as

Magnetic Resonance Imaging, CineMagnetic Resonance Imaging, InterventionalRadiosurgeryAgedFemaleHumansLung NeoplasmsMaleMiddle AgedMotionRadiotherapy DosageTreatment Outcome

Identifiers

PMID29166129
PMCPMC5965474
OpenAlexW2769982386

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.