Trial reportMovement disorders : official journal of the Movement Disorder Society2018
Pulse duration settings in subthalamic stimulation for Parkinson's disease.
Trial report in Movement disorders : official journal of the Movement Disorder Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Efficacy of short pulse and conventional deep brain stimulation in Parkinson's disease: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Pooled it
- Electrical stimulation of the nucleus basalis of meynert: a systematic review of preclinical and clinical data.Scientific reports · 2021Pooled it
- A Randomized, Double-Blinded Crossover Trial of Short Versus Conventional Pulse Width Subthalamic Deep Brain Stimulation in Parkinson's Disease.Journal of Parkinson's disease · 2022Trial
- Stimulation settings in subthalamic nucleus deep brain stimulation for parkinson's disease - a retrospective single-center observational study.Neurological research and practice · 2026Article
- Machine learning for adaptive deep brain stimulation in Parkinson's disease: closing the loop.Journal of neurology · 2023Review
- Short pulse and directional thalamic deep brain stimulation have differential effects in parkinsonian and essential tremor.Scientific reports · 2022Article
- Machine learning based brain signal decoding for intelligent adaptive deep brain stimulation.Experimental neurology · 2022Review
- Surgical Strategy for Directional Deep Brain Stimulation.Neurologia medico-chirurgica · 2022Article
- Past, Present, and Future of Deep Brain Stimulation: Hardware, Software, Imaging, Physiology and Novel Approaches.Frontiers in neurology · 2022Review
- Graph Theory on Brain Cortical Sources in Parkinson's Disease: The Analysis of 'Small World' Organization from EEG.Sensors (Basel, Switzerland) · 2021Article
- [Deep brain stimulation in neurological and psychiatric diseases].Der Nervenarzt · 2021Review
- High resolution transcranial acoustoelectric imaging of current densities from a directional deep brain stimulator.Journal of neural engineering · 2020Article
- Shorter pulse width reduces gait disturbances following deep brain stimulation for essential tremor.Journal of neurology, neurosurgery, and psychiatry · 2019Article
- Pilot Study for Considering Subthalamic Nucleus Anatomy during Stimulation Using Directional Leads.Journal of movement disorders · 2019Article
- A review of basal ganglia circuits and physiology: Application to deep brain stimulation.Parkinsonism & related disorders · 2019Review
- Toward Electrophysiology-Based Intelligent Adaptive Deep Brain Stimulation for Movement Disorders.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2019Review
- Deep Brain Stimulation Programming for Movement Disorders: Current Concepts and Evidence-Based Strategies.Frontiers in neurology · 2019Review
- Article
- An update on adaptive deep brain stimulation in Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society · 2018Review
Corrections and comments
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStimulation parameters in deep brain stimulation (DBS) of the subthalamic nucleus for Parkinson's disease (PD) are rarely tested in double-blind conditions. Evidence-based recommendations on optimal stimulator settings are needed. Results from the CUSTOM-DBS study are reported, comparing 2 pulse durations.
methodsA total of 15 patients were programmed using a pulse width of 30 µs (test) or 60 µs (control). Efficacy and side-effect thresholds and unified PD rating scale (UPDRS) III were measured in meds-off (primary outcome). The therapeutic window was the difference between patients' efficacy and side effect thresholds.
resultsThe therapeutic window was significantly larger at 30 µs than 60 µs (P = ·0009) and the efficacy (UPDRS III score) was noninferior (P = .00008).
interpretationSubthalamic neurostimulation at 30 µs versus 60 µs pulse width is equally effective on PD motor signs, is more energy efficient, and has less likelihood of stimulation-related side effects. © 2017 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.