ArticleThe Journal of infectious diseases2018
Cholera Epidemics of the Past Offer New Insights Into an Old Enemy.
Article in The Journal of infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Epidemiological characteristics and outcomes of the 2023-2024 cholera outbreak in South Yemen: a retrospective descriptive study from MSF-supported centres.BMC public health · 2026Article
- Real-time analytical insights for disease surveillance and response during the severe drought and food security crisis, Somalia 2022-2023.Conflict and health · 2026Article
- The Role of Traditional Chinese Medicine in COVID-19 Treatment: Integrating Ancient Wisdom with Modern Medicine.Current medicinal chemistry · 2026Review
- Epidemiology and clinical profile of diarrhea associated with enterotoxigenic Escherichia coli and Vibrio cholerae in Bangladesh: Findings from a hospital-based surveillance system, 2008-2023.PLoS neglected tropical diseases · 2025Article
- A Theoretical Framework to Quantify the Tradeoff Between Individual and Population Benefits of Expanded Antibiotic Use.Bulletin of mathematical biology · 2025Article
- Identifying signature features of epidemic diseases from 19th century all-cause mortality data.American journal of epidemiology · 2025Article
- Prediction and control of cholera outbreak: Study case of Cameroon.Infectious Disease Modelling · 2024Article
- Strain variation and anomalous climate synergistically influence cholera pandemics.PLoS neglected tropical diseases · 2024Article
- Clinical surveillance systems obscure the true cholera infection burden in an endemic region.Nature medicine · 2024Article
- Label-free, real-time monitoring of membrane binding events at zeptomolar concentrations using frequency-locked optical microresonators.bioRxiv : the preprint server for biology · 2023Article
- Population genomics of diarrheagenic Escherichia coli uncovers high connectivity between urban and rural communities in Ecuador.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2023Article
- Wastewater surveillance beyond COVID-19: a ranking system for communicable disease testing in the tri-county Detroit area, Michigan, USA.Frontiers in public health · 2023Article
- Customized low-cost high-throughput amplifier for electro-fluidic detection of cell volume changes in point-of-care applications.PloS one · 2022Article
- GDP effects of pandemics: a historical perspective.Empirical economics · 2022Article
- Historical and contemporary views on cholera transmission: are we repeating past discussions? Can lessons learned from cholera be applied to COVID-19?APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2021Article
- Spatial dynamics and the basic reproduction number of the 1991-1997 Cholera epidemic in Peru.PLoS neglected tropical diseases · 2020Article
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- Cholera hotspots and surveillance constraints contributing to recurrent epidemics in Tanzania.BMC research notes · 2019Article
- Cholera prevention and control in refugee settings: Successes and continued challenges.PLoS neglected tropical diseases · 2019Review
- The Epidemiology of Cholera in Zanzibar: Implications for the Zanzibar Comprehensive Cholera Elimination Plan.The Journal of infectious diseases · 2018Article
Corrections and comments
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6 authors.
Funding
Abstract
Background: Although cholera is considered the quintessential long-cycle waterborne disease, studies have emphasized the existence of short-cycle (food, household) transmission. We investigated singular Danish cholera epidemics (in 1853) to elucidate epidemiological parameters and modes of spread. Methods: Using time series data from cities with different water systems, we estimated the intrinsic transmissibility (R0). Accessing cause-specific mortality data, we studied clinical severity and age-specific impact. From physicians' narratives we established transmission chains and estimated serial intervals. Results: Epidemics were seeded by travelers from cholera-affected cities; initial transmission chains involving household members and caretakers ensued. Cholera killed 3.4%-8.9% of the populations, with highest mortality among seniors (16%) and lowest in children (2.7%). Transmissibility (R0) was 1.7-2.6 and the serial interval was estimated at 3.7 days (95% confidence interval, 2.9-4.7 days). The case fatality ratio (CFR) was high (54%-68%); using R0 we computed an adjusted CFR of 4%-5%. Conclusions: Short-cycle transmission was likely critical to early secondary transmission in historic Danish towns. The outbreaks resembled the contemporary Haiti outbreak with respect to transmissibility, age patterns, and CFR, suggesting a role for broader hygiene/sanitation interventions to control contemporary outbreaks.
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