ArticleThe Journal of infectious diseases2018
Acquisition, Persistence, and Clearance of Human Papillomavirus Infection Among Male Virgins Residing in Brazil, Mexico, and the United States.
Article in The Journal of infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Estimating incidence rates of grouped HPV types: A systematic review and comparison of the impact of different epidemiological assumptions.Papillomavirus research (Amsterdam, Netherlands) · 2019Pooled it
- Knowledge and attitude among Egyptian medical students regarding the role of human papillomavirus vaccine in prevention of oropharyngeal cancer: a questionnaire-based observational study.Scientific reports · 2025Observational
- Knowledge, attitude, and perception of the parents toward HPV vaccine administration to their children in Saudi Arabia: a cross-sectional study.Frontiers in public health · 2025Article
- Prevalence and Genotype Distribution of Human Papillomavirus Infection Among Women in Wuhan, China: A Retrospective Study.Infection and drug resistance · 2024Article
- Vaccine Effectiveness Against 12-Month Incident and Persistent Anal Human Papillomavirus Infection Among Gay, Bisexual, and Other Men Who Have Sex With Men.The Journal of infectious diseases · 2023Article
- Article
- Human papillomavirus bowel colonization in inflammatory bowel disease: A comparative case control study.Journal of family medicine and primary care · 2022Article
- Prevention and Screening of HPV Malignancies.Seminars in radiation oncology · 2021Review
- No association between HPV-status in tonsillar tissue and sexual behavior of the patients in a northern German population - Critical view of the link between HPV natural history and HPV-driven carcinogenesis.Papillomavirus research (Amsterdam, Netherlands) · 2020Article
- Incidence, clearance, persistence and factors related with high-risk anal HPV persistence in South-East Asian MSM and transgender women.AIDS (London, England) · 2020Article
- Evaluating sexual health in sex workers and men who have sex with men: the SMESH cross-sectional protocol study.BMJ open · 2019Article
- Article
- HPV Vaccination Communication Messages, Messengers, and Messaging Strategies.Journal of cancer education : the official journal of the American Association for Cancer Education · 2019Article
- Prevalence of human papillomavirus in Jeddah, Saudi Arabia.Annals of Saudi medicineArticle
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Little is known about the natural history of human papillomavirus (HPV) infection in male virgins. This study estimated the incidence and clearance of genital HPV infection and the factors associated with these measures among men who denied at baseline ever having penetrative sex. Methods: A cohort of 4123 men residing in Brazil, Mexico, and the United States were followed every 6 months for up to 10 visits. Genital exfoliated cells were collected and genotyped for 36 HPV types. Eighty-seven men were classified as virgins and included for analysis. Cox proportional hazards models identified factors associated with the incidence and clearance of genital HPV infection. Results: The incidence rates for any HPV infection among virgins who did and those who did not initiate sex during follow-up were 26.2 and 14.6 cases/1000 person-months, respectively. After penetrative sex initiation, 45.5% of men acquired HPV within 24 months. Younger age, current smoking, no recent female sex partners, and prevalent HPV infection were associated with high-risk HPV clearance. Conclusion: Virgins who did not initiate sex during follow-up still acquired HPV infection, possibly through nonpenetrative sexual contact. Further prospective cohort studies are needed to better understand factors associated with HPV acquisition and clearance in male virgins and recent nonvirgins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.