ArticleGenome biology and evolution2017
Host Genetic Variation Does Not Determine Spatio-Temporal Patterns of European Bat 1 Lyssavirus.
Article in Genome biology and evolution, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Parallel algorithms for phylogenetic inference under a structured coalescent approximation.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Case report: an atypical case of EBLV-1 infection in the long distance migrant bat Pipistrellus nathusii in mainland France.Veterinary research communications · 2026Article
- A Simple Yet Reliable 12S rRNA-Based Molecular Approach for Identifying Bat Species.Animals : an open access journal from MDPI · 2025Article
- Parallel algorithms for phylogenetic inference under a structured coalescent approximation.bioRxiv : the preprint server for biology · 2025Article
- A case report of a cat infected with European bat lyssavirus type 1, the Netherlands, October 2024.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2025Article
- Investigating the emergence of a zoonotic virus: phylogenetic analysis of European bat lyssavirus 1 in the UK.Virus evolution · 2024Article
- Transcriptomic responses of bat cells to European bat lyssavirus 1 infection under conditions simulating euthermia and hibernation.BMC immunology · 2023Article
- Comparative pathogenesis of different phylogroup I bat lyssaviruses in a standardized mouse model.PLoS neglected tropical diseases · 2022Article
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- Incursion of European Bat Lyssavirus 1 (EBLV-1) in Serotine Bats in the United Kingdom.Viruses · 2021Article
- Renewed Public Health Threat from Emerging Lyssaviruses.Viruses · 2021Article
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- Article
- Landscape genetic analyses of Cervus elaphus and Sus scrofa: comparative study and analytical developments.Heredity · 2019Article
- Mechanisms for lyssavirus persistence in non-synanthropic bats in Europe: insights from a modeling study.Scientific reports · 2019Article
- Molecular Epidemiology and Evolution of European Bat Lyssavirus 2.International journal of molecular sciences · 2018Review
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The majority of bat rabies cases in Europe are attributed to European bat 1 lyssavirus (EBLV-1), circulating mainly in serotine bats (Eptesicus serotinus). Two subtypes have been defined (EBLV-1a and EBLV-1b), each associated with a different geographical distribution. In this study, we undertake a comprehensive sequence analysis based on 80 newly obtained EBLV-1 nearly complete genome sequences from nine European countries over a 45-year period to infer selection pressures, rates of nucleotide substitution, and evolutionary time scale of these two subtypes in Europe. Our results suggest that the current lineage of EBLV-1 arose in Europe ∼600 years ago and the virus has evolved at an estimated average substitution rate of ∼4.19×10-5 subs/site/year, which is among the lowest recorded for RNA viruses. In parallel, we investigate the genetic structure of French serotine bats at both the nuclear and mitochondrial level and find that they constitute a single genetic cluster. Furthermore, Mantel tests based on interindividual distances reveal the absence of correlation between genetic distances estimated between viruses and between host individuals. Taken together, this indicates that the genetic diversity observed in our E. serotinus samples does not account for EBLV-1a and -1b segregation and dispersal in Europe.
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