ArticleAmerican journal of epidemiology2018
Multiple Imputation for Incomplete Data in Epidemiologic Studies.
Article in American journal of epidemiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 143 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
143 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Overcoming Missing Data: Accurately Predicting Cardiovascular Risk in Type 2 Diabetes, A Systematic Review.Journal of diabetes · 2025Pooled it
- Effect Modifiers of Graded Sensorimotor Retraining for Chronic Low Back Pain: A Secondary Analysis of the RESOLVE Randomized Trial.JAMA network open · 2026Trial
- Optimization of Anticoagulation Strategy During Cardiopulmonary Bypass in Neonates with Congenital Heart Disease: A Randomized Controlled Trial.Drug design, development and therapy · 2026Trial
- Trial
- Telemedical care and quality of life in patients with schizophrenia and bipolar disorder: results of a randomized controlled trial.BMC psychiatry · 2021Trial
- Psychosocial status and prenatal care of unintended pregnancies among low-income women.BMC pregnancy and childbirth · 2020Trial
- Flow Cytometric Lymphocyte Subset Enumeration for Lymphopenia Grading and C-Reactive Protein-Defined Inflammation Discrimination.Journal of clinical laboratory analysis · 2026Article
- Constructing an Evidence-Based Validity Rationale for a Multi-component Endpoint in Heterogeneous Populations.Therapeutic innovation & regulatory science · 2026Article
- Prenatal fluoride exposure and pregnancy outcomes in two US pregnancy cohorts.International journal of epidemiology · 2026Article
- Genetic susceptibility to depressive symptoms in middle-aged to older Americans: time-varying effects and effect modification by early psychosocial factors.Social psychiatry and psychiatric epidemiology · 2026Article
- Mind the Gap: Addressing Missing Person Time When Estimating Outcome Incidence in Longitudinal Data.Epidemiology (Cambridge, Mass.) · 2026Article
- Transitions Between Forms of Employment Quality and Associations With Self-Rated Health and Mental Health in the United States, 2008-2022.American journal of industrial medicine · 2026Article
- Prediction of endometrial tissue PFAS concentrations using serum levels, demographic, and reproductive factors: Findings from the Investigating Mixtures of Pollutants and Endometriosis in Tissue (IMPLANT) study.Environmental epidemiology (Philadelphia, Pa.) · 2026Article
- Is artificial intelligence a friend or foe to epidemiology?Annals of epidemiology · 2026Review
- Letter to the Editor: Enhancing the methodological rigor and interpretation of findings in a cross-sectional study on drinking water type and kidney stone risk in U.S. adults.International journal of surgery (London, England) · 2026Article
- Associations of Accelerometer-Measured Physical Activity and Sedentary Behavior With Incident Clinical Osteoporotic Fractures Among Older Women: The Objective Physical Activity and Cardiovascular Health Study.Journal of aging and physical activity · 2026Article
- Minimum combined sleep, physical activity, and nutrition variations associated with lifeSPAN and healthSPAN improvements: a population cohort study.EClinicalMedicine · 2026Article
- Occupational exposures and kidney cancer among 25 000 male offshore petroleum industry workers: relative risks and healthy worker survivor bias.American journal of epidemiology · 2026Article
- Evidence based targeting of districts for active surveillance of skin-related neglected tropical diseases in Ghana.PLOS global public health · 2026Article
- Article
83 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Epidemiologic studies are frequently susceptible to missing information. Omitting observations with missing variables remains a common strategy in epidemiologic studies, yet this simple approach can often severely bias parameter estimates of interest if the values are not missing completely at random. Even when missingness is completely random, complete-case analysis can reduce the efficiency of estimated parameters, because large amounts of available data are simply tossed out with the incomplete observations. Alternative methods for mitigating the influence of missing information, such as multiple imputation, are becoming an increasing popular strategy in order to retain all available information, reduce potential bias, and improve efficiency in parameter estimation. In this paper, we describe the theoretical underpinnings of multiple imputation, and we illustrate application of this method as part of a collaborative challenge to assess the performance of various techniques for dealing with missing data (Am J Epidemiol. 2018;187(3):568-575). We detail the steps necessary to perform multiple imputation on a subset of data from the Collaborative Perinatal Project (1959-1974), where the goal is to estimate the odds of spontaneous abortion associated with smoking during pregnancy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.